Testicular Neoplasms (Testicular Cancer)

Tumors or cancer of the TESTIS. Germ cell tumors (GERMINOMA) of the testis constitute 95% of all testicular neoplasms.

Also Known As:

Testicular Cancer; Cancer of the Testis; Neoplasms, Testicular; Neoplasms, Testis; Testicular Tumors; Testis Neoplasms; Tumor of Rete Testis; Cancer, Testicular; Cancer, Testis; Cancers, Testicular; Cancers, Testis; Neoplasm, Testicular; Neoplasm, Testis; Rete Testis Tumor; Rete Testis Tumors; Testicular Cancers; Testis Cancers; Testis Neoplasm; Testis Tumor, Rete; Testis Tumors, Rete; Tumor, Testicular; Tumors, Testicular; Cancer of Testis; Cancer of the Testes; Testicular Neoplasm; Testicular Tumor; Testis Cancer

Networked: 6692 relevant articles (271 outcomes, 659 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Neoplasms (Cancer)
2.	Testicular Neoplasms (Testicular Cancer)
3.	Neoplasm Metastasis (Metastasis)
4.	Germ Cell and Embryonal Neoplasms (Germ Cell Tumor)
5.	Breast Neoplasms (Breast Cancer)

Experts

1.	Old, Lloyd J: 79 articles (01/2013 - 02/2002)
2.	Jungbluth, Achim A: 56 articles (05/2022 - 02/2002)
3.	Gnjatic, Sacha: 56 articles (07/2021 - 12/2002)
4.	Richie, Jerome P: 51 articles (08/2023 - 09/2002)
5.	Einhorn, Lawrence H: 47 articles (03/2024 - 02/2002)
6.	Chen, Yao-Tseng: 46 articles (05/2015 - 04/2002)
7.	Fosså, Sophie D: 41 articles (03/2024 - 03/2003)
8.	Ritter, Gerd: 41 articles (01/2016 - 04/2002)
9.	Foster, Richard S: 33 articles (10/2021 - 10/2002)
10.	Gietema, Jourik A: 32 articles (12/2023 - 06/2005)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Testicular Neoplasms:

1.	Cisplatin (Platino)FDA LinkGeneric 01/01/1992 - "The descriptive epidemiological study of the data of the literature reveals a considerable improvement in the prognosis of testicular cancers, particularly since the introduction of cisplatin in the 1980. " 01/01/1992 - "The descriptive epidemiological study of the data of the literature reveals a considerable improvement in the prognosis of testicular cancers, particularly since the introduction of cisplatin in the 1980. " 08/30/2002 - "Cisplatin is an effective agent for the treatment of testicular cancer. " 09/01/2000 - "As a result of the introduction of effective cisplatin-based chemotherapeutic regimens into the clinical routine, even patients with metastatic testicular cancer at initial diagnosis can be cured of their disease. " 12/02/1997 - "The anticancer drug cisplatin is particularly effective against testicular tumors. "
2.	AntigensIBA 08/01/2006 - "Directed evolution for improved secretion of cancer-testis antigen NY-ESO-1 from yeast." 10/16/2023 - "This study delves into the cytotoxicity and functional characteristics of in vitro-cultured T-lymphocytes, equipped with a TCR designed to precisely target the cancer-testis antigen NY-ESO-1. " 10/13/2023 - "In this study, we investigated the cytotoxicity and functional attributes of in vitro-generated T-lymphocytes, engineered with a TCR-like CAR receptor precisely targeting the cancer testis antigen MAGE-A4. " 04/01/2023 - "In the present study, we screened for potential cancer-testis antigens (CTAs) by comparing the bioinformatics of CD8+ T effector memory (Tem) cell infiltration between MSI-H and non-MSI-H CRC. " 01/01/2023 - "Although none of the foregoing therapeutic targets were discovered by proteomics, newer targets discovered by proteomics, including HSP90 and cancer/testis antigens, are being tested also in clinical trials. "
3.	Etoposide (VP 16)FDA LinkGeneric 03/01/1986 - "[Complete remission obtained in advanced testicular cancer treated by etoposide (NK-171)]." 10/01/1986 - "One patient with a testicular tumor who was given oral etoposide achieved complete remission for 23 months. " 04/01/1989 - "The impact of etoposide on prolonging survival in lung and testicular cancer is addressed, and studies evaluating the pharmacodynamics of etoposide are described. " 06/01/2009 - "Since testicular cancer primarily affects young males, we used pubertal rats (21 days old) as a model to determine different apoptotic parameters after etoposide treatment in healthy testes. " 06/01/2009 - "Etoposide is widely used in the treatment of patients with testicular cancer. "
4.	PlatinumIBA 10/01/1994 - "Pharmacokinetic and toxicity data from 23 patients with ovarian or testicular cancer were combined with published values from four other centers and the relationships between plasma clearance of ultrafilterable platinum and GFR, and between percentage reduction in platelet count and area under the plasma platinum curve were determined. " 01/01/2022 - "These preliminary findings may have important implications for the reproductive health of survivors of advanced testicular cancer, further study is needed to assess the relationship between platinum persistence in semen and recovery of fertility postchemotherapy." 01/01/2022 - "Platinum is detected in semen of testicular cancer survivors at higher levels than matched blood samples. " 05/01/2020 - "Evaluation of nuclear NF-κB, transglutaminase2, and ERCC1 as predictors of platinum resistance in testicular tumors." 01/01/2020 - "Genomic landscape of platinum resistant and sensitive testicular cancers."
5.	Bleomycin (Blenoxane)FDA LinkGeneric 12/01/2020 - "A population-based study of pulmonary monitoring and toxicity for patients with testicular cancer treated with bleomycin." 01/01/2015 - "In this study, we investigated apoptotic effects of bleomycin, TRAIL, and their combined application in NTera-2 and NCCIT testicular cancer cell lines. " 06/01/2013 - "However, no study has been carried out so far to elucidate its interaction with bleomycin in testicular cancer cells. " 01/01/2012 - "However, to date no study has been carried out to elucidate its anticancer activity and interaction with bleomycin in testicular cancer cells. " 11/01/2003 - "Several clinical trials have focused on eliminating bleomycin from the regimen or reducing the bleomycin dose for testicular cancer patients with good prognosis. "
6.	Ifosfamide FDA LinkGeneric 05/01/1994 - "In both human testicular cancer cell lines, H 12.1 and 2102 EP, ifosfamide demonstrated anti-tumour activity as a single agent. " 04/01/1990 - "Ifosfamide in testicular cancer." 03/01/1989 - "Ifosfamide approved for treatment of testicular cancer." 02/01/1989 - "The role of ifosfamide in testicular cancer." 02/01/1989 - "Ifosfamide in testicular cancer: the Indiana University experience."
7.	Chorionic Gonadotropin (Human Chorionic Gonadotropin)FDA LinkGeneric 01/01/2013 - "Intratubular trophoblasts in the contralateral testis caused elevation of serum human chorionic gonadotropin following complete remission of stage II testicular tumor: a case report." 12/01/1989 - "Reduced metabolic clearance of acidic variants of human choriogonadotropin from patients with testicular cancer." 08/01/1981 - "Improved human chorionic gonadotropin detection with carboxyl-terminal radioimmunoassay of the beta subunit on concentrated 24-hour urine in patients with testicular cancer." 01/01/2023 - "Comparison between free β subunit of human chorionic gonadotropin (hCG) and total hCG assays in adults with testicular cancer." 01/01/2020 - "A step forward in identifying the right human chorionic gonadotropin assay for testicular cancer."
8.	Tumor Biomarkers (Tumor Markers)IBA 07/01/1980 - "Improved staging for testicular cancer using biologic tumor markers: a prospective study." 01/01/2021 - "The main inclusion criteria for AS in patients with STMs were lack of risk factors of testicular cancer, no features of disseminated disease, negative tumor markers, non-palpable lesion that did not exceed 10 mm. Mean follow-up time of AS across the studies ranged from 9.6 to 29.6 months. " 03/01/2009 - "The results of this study demonstrate differences and similarities between tumor marker expression of testicular tumors in dogs and humans. " 04/01/1989 - "Chest film, computerized axial tomography, retroperitoneal ultrasound study and specific tumor markers were all negative which indicated stage 1 testicular tumor confined to the scrotal region according to Dixon and Moore's staging. " 03/01/1984 - "[Studies on the tumor markers in the germinal testicular tumors. "
9.	Vinblastine (Vinblastine Sulfate)FDA Link 08/01/1988 - "The clinical pharmacokinetics of vinblastine administered by continuous 5-day infusion (3 mg/m2/day) was studied in 12 patients with primary testicular cancer. " 08/01/1988 - "The correlation of vinblastine pharmacokinetics to toxicity in testicular cancer patients." 05/01/1970 - "Vinblastine in the management of testicular cancer." 06/01/1986 - "PVB with a 0.2-mg/kg vinblastine dosage is very effective and well-tolerated therapy in selected good-risk patients with disseminated germinal testis cancer." 09/01/1981 - "Our third-generation study, done in conjunction with the Southeastern Cancer Study Group, tested the hypothesis of whether maintenance vinblastine was necessary to ensure optimal cure rates in disseminated testicular cancer. "
10.	alpha-Fetoproteins (alpha-Fetoprotein)IBA 01/01/2021 - "After the treatment, when no other indication of testicular cancer than an elevated alpha-fetoprotein level is present, the patient should be managed by ongoing surveillance." 01/01/2021 - "Post-treatment persistent alpha-fetoprotein elevation in a patient with testicular cancer." 01/01/2012 - "Variations in normal serum alpha-fetoprotein (AFP) levels in patients with testicular cancer on surveillance." 10/01/2010 - "The following report describes a case of inherited elevation of alpha-fetoprotein (AFP) in a young male suspected for testicular cancer. " 01/01/2008 - "A 42-year-old man, with a clinical history of right testicular cancer, was referred to our hospital with elevated serum alpha-fetoprotein (AFP) level. "

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 02/01/1988 - "The testicular cancer has been most effectively treated with the combined chemotherapy. " 11/01/1995 - "In patients with refractory nonseminomatous testicular cancer there have been a number of studies performed with high-dose chemotherapy showing a 15% complete and prolonged remission. " 01/01/2006 - "We conclude that in this special case aggressive surgical management following chemotherapy was very effective in controlling the disseminated testicular tumor." 03/01/1997 - "We report a patient who experienced relapse 11 years after the initial diagnosis of advanced testicular cancer and who achieved a sustained complete remission with salvage chemotherapy alone." 01/01/1983 - "Addition of surgery to cytoreductive chemotherapy has increased the number of patients with complete remission after advanced testicular cancer. "
2.	Therapeutics 11/01/2022 - "This case presents a unique danger of adjuvant radiation in testicular cancer survivors, demonstrates the efficacy of multimodal therapy with GU SCC, and describes a highly unusual histologic finding." 06/26/2010 - "Detailed recommendations for the treatment of testicular cancer exist and due to the stringent application of the standard therapies, most patients can nowadays be cured. " 01/01/1991 - "In conclusion, most cured testicular cancer patients enjoy a normal life if precaution is taken to reduce therapy-related side effects to a minimum. " 02/12/2007 - "The better survival observed is largely attributable to improved treatment, and the trend in reducing the toxicity of therapy should continue to reduce future health risks in testicular cancer survivors." 07/01/1993 - "However, adequate combination therapy might be effective for the far-advanced testicular tumor."
3.	Combination Drug Therapy (Combination Chemotherapy) 05/01/2017 - "Despite remarkable results with frontline and salvage combination chemotherapy, metastatic testicular cancer remains incurable in approximately 10% of patients, and novel treatment approaches are warranted. " 02/01/2010 - "The current study assesses the outcome for a modern, unselected patient population with disseminated testicular cancer with particular emphasis on those achieving a radiographic complete remission to combination chemotherapy. " 09/01/1984 - "The combination chemotherapy with CDDP appears to be effective in nonseminomatous testicular tumor. " 03/01/2020 - "Since the introduction of polychemotherapy in the 1970s, the prognosis of malignant testicular tumors has improved enormously and has become a curable disease, even in the case of recurrence. " 12/01/2015 - "However, they develop rarely in elderly men over 70 years old, and there are few reports about the information of combination chemotherapy for elderly testicular tumor patients. "
4.	Lymph Node Excision (Lymph Node Dissection) 01/01/2023 - "Retroperitoneal lymph node dissection (RPLND) is an effective treatment for testicular tumors. " 01/01/2023 - "The R-RPLND and O-RPLND/L-RPLND provide safe and effective retroperitoneal lymph node dissection for testicular cancer. " 11/01/2017 - "A midline extraperitoneal approach for retroperitoneal lymph node dissection in testicular cancer is safe and effective and leads to faster return of bowel function and earlier discharge." 04/01/2003 - "Repeat retroperitoneal lymph node dissection is safe and effective in the majority of patients with recurrent or residual retroperitoneal masses after initial multimodality treatments for metastatic testis cancer. " 01/01/2024 - "For patients with testicular tumors who need the surgical management, open retroperitoneal lymph node dissection (O-RPLND) is considered the gold standard treatment. "
5.	Orchiectomy (Orchidectomy) 07/14/2017 - "Although radical orchiectomy is the gold standard for the treatment of testicular neoplasms, a conservative approach with partial orchiectomy or tumourectomy may be the best treatment option for these patients, allowing the preservation of endocrine function, fertility and body image. " 09/01/1996 - "Over the last few years, prognostic factors in the primary testicular tumor have helped clinicians make more rational decisions about whether RPLND or surveillance should follow initial orchiectomy. " 10/01/2023 - "Radical inguinal orchidectomy is the gold standard for the diagnosis and treatment of testicular cancer, which is confined to the scrotum and is generally well tolerated. " 12/01/2020 - "Radical inguinal orchidectomy: the gold standard for initial management of testicular cancer." 01/23/2014 - "The gold standard for treatment of a testicular neoplasm is the radical orchiectomy. "