Abstract |
The induction of pancreatic ductal-ductular adenomas (P = .05) and carcinomas (P less than .0001) by N-nitrosobis(2-oxopropyl)amine [(BOP) CAS: 60599-38-4; 2,2'-dioxo- N-nitrosodipropylamine] in Syrian golden hamsters was inhibited by nicotinamide (NA) (350 mg/kg body wt, ip) administered 10 minutes before and 3 hours after a single dose of BOP (10 mg/kg body wt, sc). The anticancer effect of NA and its relatively low toxicity in humans may provide a new lead in human cancer prevention.
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Authors | P M Pour, T Lawson |
Journal | Journal of the National Cancer Institute
(J Natl Cancer Inst)
Vol. 73
Issue 3
Pg. 767-70
(Sep 1984)
ISSN: 0027-8874 [Print] United States |
PMID | 6236323
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Carcinogens
- Nitrosamines
- Niacinamide
- nitrosobis(2-oxopropyl)amine
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Topics |
- Adenoma
(chemically induced, pathology)
- Animals
- Carcinogens
(toxicity)
- Carcinoma
(chemically induced, pathology)
- Cricetinae
- Female
- Male
- Mesocricetus
- Niacinamide
(pharmacology)
- Nitrosamines
(toxicity)
- Pancreatic Neoplasms
(chemically induced, pathology)
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