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Modification of pancreatic carcinogenesis in the hamster model. XV. Preventive effect of nicotinamide.

Abstract
The induction of pancreatic ductal-ductular adenomas (P = .05) and carcinomas (P less than .0001) by N-nitrosobis(2-oxopropyl)amine [(BOP) CAS: 60599-38-4; 2,2'-dioxo-N-nitrosodipropylamine] in Syrian golden hamsters was inhibited by nicotinamide (NA) (350 mg/kg body wt, ip) administered 10 minutes before and 3 hours after a single dose of BOP (10 mg/kg body wt, sc). The anticancer effect of NA and its relatively low toxicity in humans may provide a new lead in human cancer prevention.
AuthorsP M Pour, T Lawson
JournalJournal of the National Cancer Institute (J Natl Cancer Inst) Vol. 73 Issue 3 Pg. 767-70 (Sep 1984) ISSN: 0027-8874 [Print] United States
PMID6236323 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Carcinogens
  • Nitrosamines
  • Niacinamide
  • nitrosobis(2-oxopropyl)amine
Topics
  • Adenoma (chemically induced, pathology)
  • Animals
  • Carcinogens (toxicity)
  • Carcinoma (chemically induced, pathology)
  • Cricetinae
  • Female
  • Male
  • Mesocricetus
  • Niacinamide (pharmacology)
  • Nitrosamines (toxicity)
  • Pancreatic Neoplasms (chemically induced, pathology)

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