HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

N-nitroso(di-n-propyl)amine

Also Known As:

N,N-dipropylnitrosamine; N-nitrosodipropylamine; dipropylnitrosamine; n-Nitrosodi-n-propylamine

Networked: 6 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Nitroso Compounds: 446
  - Nitrosamines: 1539
    - N-nitroso(di-n-propyl)amine: 6

Related Diseases

1.	Pancreatic Neoplasms (Pancreatic Cancer) 10/01/1983 - "Studies with oxidized derivatives of N-nitrosodi-n-propylamine suggested a structure-activity relationship between pancreatic cancer induction in Syrian hamsters and position and degree of nitrosamine oxidation. "
2.	Carcinogenesis 05/01/1984 - "The effect of exogenous insulin, which has been known to suppress beta-cell function of islets, was investigated on pancreatic carcinogenesis induced by N-nitrosobis(2-oxopropyl) amine [(BOP) CAS: 60599-38-4; 2,2'-dioxo-N-nitrosodipropylamine]. " 01/01/1997 - "In the multi-organ carcinogenesis bioassay, rats were given DEN, N-methyl-N-nitrosourea, N-butyl-N-(4-hydroxybutyl)nitrosamine, N,N'-dimethylhydrazine, and dihydroxy-dipropylnitrosamine during the first 4 weeks, followed by test chemicals for 24 weeks. "
3.	Neoplasms (Cancer) 02/01/1979 - "N-Nitrosodi-n-propylamine was a potent carcinogen but less so than N-nitrosodiethylamine and gave the same spectrum of tumors. " 08/01/1981 - "The metabolic fate of N, N-dipropylnitrosamine (DPN) and N, N-dipentyl-(=diamyl) nitrosamine (DAN), which induced tumors principally in the liver and esophagus but not in the urinary bladder, was studied in the rat, in order to elucidate the reason for this lack of carcinogenicity to the urinary bladder in contrast with the butyl homolog, N, N-dibutylnitrosamine (DBN), a potent bladder carcinogen. "
4.	Carcinoma (Carcinomatosis) 09/01/1984 - "The induction of pancreatic ductal-ductular adenomas (P = .05) and carcinomas (P less than .0001) by N-nitrosobis(2-oxopropyl)amine [(BOP) CAS: 60599-38-4; 2,2'-dioxo-N-nitrosodipropylamine] in Syrian golden hamsters was inhibited by nicotinamide (NA) (350 mg/kg body wt, ip) administered 10 minutes before and 3 hours after a single dose of BOP (10 mg/kg body wt, sc). "
5.	Adenoma (Adenomas) 09/01/1984 - "The induction of pancreatic ductal-ductular adenomas (P = .05) and carcinomas (P less than .0001) by N-nitrosobis(2-oxopropyl)amine [(BOP) CAS: 60599-38-4; 2,2'-dioxo-N-nitrosodipropylamine] in Syrian golden hamsters was inhibited by nicotinamide (NA) (350 mg/kg body wt, ip) administered 10 minutes before and 3 hours after a single dose of BOP (10 mg/kg body wt, sc). "

Related Drugs and Biologics

1.	Nitrosamines
2.	Carcinogens
3.	1,2-Dimethylhydrazine (1,2 Dimethylhydrazine)
4.	Niacinamide (Nicotinamide)
5.	NAD (NADH)
6.	Methylnitrosourea (N-Methyl-N-nitrosourea)
7.	Insulin (Novolin)
8.	Diethylnitrosamine (N-Nitrosodiethylamine)
9.	Butylhydroxybutylnitrosamine
10.	Amines