HLA antigens and atopic features in steroid-responsive nephrotic syndrome of childhood.

Abstract

Atopic systems were more common in children with steroid-responsive nephrotic syndrome (S.R.N.S.) than in matched controls, and HLA-B12 was more common in children with S.R.N.S. than in adult controls. Atopic symptoms (particularly hayfever), positive prick tests with grass pollen antigens, and a higher mean serum concentration of IgE antibody to timothy grass pollen were more common in nephrotic children with HLA-B12 than in those without HLA-B12. There was also an increased frequency of the haplotype HLA-A1 and HLA-B8, mainly among the non-atopic patients.

• Authors: P D Thomson, C R Stokes, T M Barratt, M W Turner, J F Soothill
• Journal: Lancet (London, England) (Lancet) Vol. 2 Issue 7989 Pg. 765-8 (Oct 09 1976) ISSN: 0140-6736 [Print] England
• PMID: 61442 (Publication Type: Journal Article)

Chemical References

• HLA Antigens
• Histocompatibility Antigens
• Immunoglobulin E
• Cyclophosphamide
• Prednisolone

Topics

• Adolescent
• Child
• Child, Preschool
• Cyclophosphamide (therapeutic use)
• HLA Antigens (analysis)
• Histocompatibility Antigens (analysis)
• Humans
• Hypersensitivity, Immediate (complications, diagnosis)
• Immunoglobulin E (isolation & purification)
• Nephrotic Syndrome (drug therapy, etiology, immunology)
• Pollen
• Prednisolone (therapeutic use)
• Skin Tests