Abstract |
In vitro sensitivity of an established cell line from human urinary bladder cancer to various chemotherapeutic agents was determined by 14C-leucine incorporation into the target cells. Of 12 drugs tested, Carboquone, Neocarzinostatin, Actinomycin D, Adriamycin, Mitomycin C and Chromomycin A3 produced intensive cytotoxic effects, while Thio-Tepa, Bleomycin, 5-Fluorouracil and Vincirstine were less cytotoxic, Intravesical instillation of Carboquone, one of the most toxic agents in vitro, resulted in complete or partial tumor remission in 6 of 9 patients with bladder cancer. Prophylactic effects of periodic intravesical Carboquone were also indicated in 7 of 8 patients who had experienced recurring superficial bladder tumors.
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Authors | T Kato, R Nemoto, T Nishimoto, I Kumagai, K Miura |
Journal | Cancer
(Cancer)
Vol. 44
Issue 1
Pg. 58-63
(Jul 1979)
ISSN: 0008-543X [Print] United States |
PMID | 455264
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Antineoplastic Agents
- Azirines
- Carbazilquinone
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Topics |
- Antineoplastic Agents
(administration & dosage, pharmacology)
- Azirines
(pharmacology)
- Carbazilquinone
(administration & dosage, pharmacology)
- Carcinoma, Transitional Cell
(drug therapy)
- Cell Line
- Cell Survival
(drug effects)
- Drug Evaluation, Preclinical
- Drug Resistance
- Humans
- Neoplasms, Experimental
(drug therapy)
- Remission, Spontaneous
- Urinary Bladder Neoplasms
(drug therapy)
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