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Mitomycin (Mitomycin-C)

An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.

Also Known As:

Mitomycin-C; Mutamycin; Ametycine; Mitocin-C; NSC-26980; Mitocin C; MitocinC; NSC 26980; NSC26980; Mitomycin C; Azirino(2',3':3,4)pyrrolo(1,2-a)indole-4,7-dione, 6-amino-8-(((aminocarbonyl)oxy)methyl)-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methyl-, (1aS-(1aalpha,8beta,8aalpha,8balpha))-

Networked: 6200 relevant articles (545 outcomes, 1067 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Tanihara, Hidenobu: 13 articles (06/2014 - 03/2007)
2.	D'Andrea, Alan D: 13 articles (12/2011 - 07/2002)
3.	Gedde, Steven J: 11 articles (06/2014 - 08/2005)
4.	Inatani, Masaru: 11 articles (06/2014 - 03/2007)
5.	Joenje, Hans: 10 articles (01/2012 - 02/2002)
6.	Cunningham, D: 9 articles (03/2015 - 04/2002)
7.	Lønning, Per Eystein: 9 articles (12/2014 - 11/2003)
8.	Cunningham, David: 9 articles (08/2014 - 07/2002)
9.	Inoue, Toshihiro: 9 articles (06/2014 - 03/2007)
10.	Schiffman, Joyce C: 9 articles (06/2014 - 08/2005)

Related Diseases

1.	Neoplasms (Cancer) 11/01/1988 - "Mitomycin C is effective for treatment of residual superficial tumor and when instilled regularly after complete transurethral resection (prophylaxis). " 02/01/2000 - "Phase III trials have shown that mitomycin C can be as effective as BCG in the management of papillary tumors; however, BCG is more effective in patients with CIS and high-risk superficial tumors." 02/01/1998 - "A significant reduction in the number of tumor colonies was obtained when repeated subcutaneous administrations of mitomycin C-blocked transfectant cells were given, commencing 3 days after an intravenous challenge with TSA cells. " 05/01/1988 - "In combination with JTX, mitomycin C resulted in a significantly greater tumor growth inhibition than could be obtained with mitomycin C alone. " 01/01/1985 - "Subsequent tests indicated that the ip inoculation of X-irradiated or mitomycin-treated tumor cells of low-metastatic clones elicited a significantly greater peritoneal infiltration of macrophages than did tumor cells of high-metastatic clones. "
2.	Glaucoma 03/01/1998 - "Adjunctive mitomycin C significantly (P < .05) improved the filtration outcome of the primary glaucoma triple procedure in the subgroups with each of the three prognostic factors for filtration failure of primary glaucoma triple procedure. " 07/01/2002 - "Mitomycin and rAd.p21 were effective in preventing fibroproliferation and wound healing in a rabbit model of glaucoma surgery. " 03/01/2000 - "In this retrospective case series with relatively short follow-ups, AGV implantation with mitomycin C in refractory glaucoma appears to be effective without increased complication rates." 10/01/2009 - "To evaluate the safety and efficacy of deep sclerectomy with implant and mitomycin C in uveitic glaucoma. " 01/01/1995 - "The authors assessed the efficacy of adjunctive intraoperative mitomycin C to produce lower intraocular pressures (IOPs) in patients with complicated glaucoma who underwent double-plate Molteno implantation. "
3.	Pterygium 03/01/2010 - "Intra-operative application of 0.4mg/ml Mitomycin C is very effective in reduction of recurrence of pterygium after excision. " 05/01/2005 - "Despite the established efficacy of mitomycin C (MMC) in preventing recurrence after pterygium surgery, there is no consensus on the optimal operative technique or dose of MMC. " 05/01/2005 - "Safety and efficacy of the technique of complete tenon's membrane excision and mitomycin C in pterygium surgery." 06/01/2000 - "The intraoperative administration of 0.04% mitomycin C is more effective than beta irradiation as an adjunctive treatment for pterygium surgery in the patient population examined in this study." 09/01/2013 - "Pterygium excision using bulbar conjunctival autograft with intraoperative mitomycin C was effective in primary pterygium."
4.	Urinary Bladder Neoplasms (Bladder Cancer) 09/01/2011 - "Bladder cancer: EMDA mitomycin before TURBT is the best treatment for non-muscle-invasive disease." 01/01/1992 - "at the dose of 50 micrograms per animal per day during 6-week period of promotion with mitomycin C, the incidence of urinary bladder cancer was dramatically reduced. " 08/01/2015 - "This study sought to determine if the addition of perioperative mitomycin C (MMC) to treatment with bacillus Calmette-Guérin (BCG) after transurethral resection (TURBT) is superior to TURBT plus BCG alone in high grade non-muscle invasive bladder cancer (NMIBC). " 03/01/2004 - "Intravesical bacillus Calmette-Guérin is superior to mitomycin C in reducing tumour recurrence in high-risk superficial bladder cancer: a meta-analysis of randomized trials." 11/01/1998 - "We study toxicity and efficacy of sequential intravesical therapy with mitomycin C and bacillus Calmette-Guerin (BCG) in patients with intermediate or high risk superficial bladder cancer compared to the use of intravesical mitomycin C alone. "
5.	Carcinoma (Carcinomatosis) 01/01/1997 - "Based on a few previous studies, intra-peritoneal hyperthermic perfusion (IPHP) with Mitomycin C could become a beneficial treatment for peritoneal carcinomatosis. " 06/01/2009 - "Topical mitomycin C may be effective for treating pagetoid spread of sebaceous carcinoma of limbal origin." 04/01/2004 - "To compare the therapeutic efficacy of intravesical bacille Calmette-Guérin (BCG) with mitomycin C (MMC) on progression of Stage Ta and T1 bladder carcinoma. " 01/01/2003 - "We compare the therapeutic efficacy and toxicity of intravesical bacillus Calmette-Guerin (BCG) with mitomycin C on recurrence of stages Ta and T1 bladder carcinoma. " 11/01/2002 - "Preliminary evidence suggests that topical mitomycin-C is effective treatment for pagetoid invasion of the conjunctiva by sebaceous gland carcinoma. "

Related Drugs and Biologics

1.	Fluorouracil (Carac)
2.	Doxorubicin (Adriamycin)
3.	Cisplatin (Platino)
4.	Epirubicin (Ellence)
5.	Cyclophosphamide (Cytoxan)
6.	Vinblastine (Vinblastine Sulfate)
7.	capecitabine (Xeloda)
8.	bevacizumab
9.	Vincristine (Oncovin)
10.	Tegafur

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Trabeculectomy (Trabeculoplasty)
3.	Filtering Surgery
4.	Adjuvant Chemotherapy
5.	Photorefractive Keratectomy