[Mechanisms of thrombocyte aggregation in experimental hypoparathyroidism].

Abstract

Inhibitors of thromboxane synthetase (imidazole), cyclooxygenase (indomethacin), phospholipase A2 (Mepacrine) were used in the experiments on rabbits with experimental hypoparathyroidism to study the role of aggregation factors in the changes of ADP- and collagen-induced platelet aggregation. The enhancement of arachidonic acid metabolism and the release of platelet aggregation factor are discussed.

• Authors: Iu Ia Chursina, E A Amroian, D N Khudaverdian
• Journal: Biulleten' eksperimental'noi biologii i meditsiny (Biull Eksp Biol Med) Vol. 102 Issue 12 Pg. 666-8 (Dec 1986) ISSN: 0365-9615 [Print] Russia (Federation)
• Vernacular Title: Issledovanie mekhanizmov agregatsii trombotsitov pri éksperimental'nom gipoparatireoze.
• PMID: 3801615 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Imidazoles
• Thromboxane A2
• Adenosine Diphosphate
• imidazole
• Collagen
• Indomethacin

Topics

• Adenosine Diphosphate (pharmacology)
• Animals
• Collagen (pharmacology)
• Hypoparathyroidism (blood)
• Imidazoles (pharmacology)
• Indomethacin (pharmacology)
• Platelet Aggregation (drug effects)
• Rabbits
• Thromboxane A2 (pharmacology)