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Quinacrine (Mepacrine)

An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2.

Also Known As:

Mepacrine; Acrichine; Atabrine; Atebrin; Quinacrine Dihydrochloride; Quinacrine Dihydrochloride, Dihydrate; Quinacrine Dihyrochloride, (R)-Isomer; Quinacrine Dihyrochloride, (S)-Isomer; Quinacrine Dimesylate; Quinacrine Hydrochloride; Quinacrine Monoacetate; Quinacrine Monohydrochloride; Quinacrine Monomesylate; Quinacrine, (+-)-Isomer; Quinacrine, (R)-Isomer; Quinacrine, (S)-Isomer; Dihydrochloride, Quinacrine; Dimesylate, Quinacrine; Hydrochloride, Quinacrine; Monoacetate, Quinacrine; Monohydrochloride, Quinacrine; Monomesylate, Quinacrine; 1,4-Pentanediamine, N4-(6-chloro-2-methoxy-9-acridinyl)-N1,N1-diethyl-

Networked: 733 relevant articles (47 outcomes, 73 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 60
- 3-Ring Heterocyclic Compounds
  - Acridines: 28
    - Aminoacridines: 3
      - Quinacrine: 733
        Quinacrine Mustard: 10
        pyridoxine drug combination quinacrine chloroquine calcium pantothenate aminobenzoic acid: 3
        quinacrine drug combination ethosuximide: 2
        dimethylquinacrine
        Preparation ABP
        quinacrine half mustard

Experts

1.	Prusiner, Stanley B: 6 articles (12/2013 - 03/2003)
2.	Lippes, Jack: 5 articles (08/2015 - 07/2009)
3.	Lu, Wan-Liang: 4 articles (08/2015 - 08/2008)
4.	Sokal, David C: 4 articles (03/2010 - 07/2008)
5.	Kataoka, Yasufumi: 4 articles (05/2007 - 01/2004)
6.	Das, Dipon: 3 articles (11/2015 - 01/2012)
7.	Kundu, Chanakya Nath: 3 articles (11/2015 - 01/2012)
8.	Sun, Meng-Ge: 3 articles (08/2015 - 01/2012)
9.	Li, Xue-Tao: 3 articles (08/2015 - 08/2014)
10.	Shi, Ji-Feng: 3 articles (08/2015 - 01/2012)

Related Diseases

1.	Infection 01/01/2001 - "Patients who have resistant infection can usually be cured by a prolonged course of treatment with a combination of a nitroimidazole with quinacrine." 01/01/2013 - "Here, we report that quinacrine was highly active against EV71, protecting cells from EV71 infection. " 09/01/2006 - "Quinacrine significantly potentiated the anti-MAC activity of PA, suggesting the usefulness of this combination in the clinical control of MAC infection." 06/01/1998 - "vivax infections, whereas 100 mg of atebrin daily controlled symptoms of P. " 11/01/1983 - "Quinacrine alone is ineffective in therapy of chronic HBV infection. "
2.	Malaria 01/01/1999 - "In the course of WWII malaria casualties dropped beyond expectation due to an improved usage of quinacrine (Atebrine) which was based on new knowledge in pharmacokinetics. " 04/01/1951 - "[On the virulence of malaria in Greece, and the efficacy of various forms of atabrine therapy]." 11/01/1946 - "Studies on atabrine suppression of malaria; an evaluation of atabrine suppression in the field." 10/01/1945 - "Psychosis following administration of quinacrine hydrochloride for malaria; neuropsychiatric study of a case." 03/01/2015 - "Quinacrine is a relatively non-toxic drug, once given almost exclusively for malaria. "
3.	Neoplasms (Cancer) 05/10/2011 - "Quinacrine, a drug with antimalarial and anticancer activities that inhibits NF-κB and activates p53, has progressed into phase II clinical trials in cancer. " 03/01/2010 - "We feel the totality of the information provided herein dictates that the doses (70/70, 70/250 and 70/350 mg/kg quinacrine) causing uterine tumors in their study clearly exceeded the maximum tolerated dose (MTD) typically administered in chronic cancer studies. " 10/01/1955 - "Studies on the administration of quinacrine to tumor-bearing mice." 04/01/2015 - "A rat carcinogenicity bioassay (CaBio) of quinacrine was reanalyzed to investigate its mode of tumor induction. " 04/01/2015 - "A critical examination of the mode of action of quinacrine in the reproductive tract in a 2-year rat cancer bioassay and its implications for human clinical use."
4.	Prion Diseases (Transmissible Spongiform Encephalopathies) 11/02/2006 - "The most potent target compound 2a revealed an EC(50) value of 20 nM determined with a cell model of prion disease, thus substantially improving the antiprion efficacy of quinacrine." 11/29/2004 - "In a cell-based assay, quinacrine inhibits the conversion of normal host prion protein (PrPC) to PrPSc at a half-maximal concentration of 300 nM. While these data suggest that quinacrine may be beneficial in the treatment of prion disease, its penetration into brain tissue has not been extensively studied. " 11/29/2004 - "The documented extensive brain tissue penetration is encouraging suggesting quinacrine might be useful in the treatment of prion disease. " 11/29/2004 - "If quinacrine penetrates brain tissue in concentrations exceeding that demonstrated for in vitro inhibition of PrPSc, it may be useful in the treatment of prion disease. " 04/01/2009 - "Safety and efficacy of quinacrine in human prion disease (PRION-1 study): a patient-preference trial."
5.	Giardiasis 03/01/1958 - "[Therapy of lambliasis; 52 cases effectively treated with combined mepacrine & rodoprequine]." 01/01/2012 - "The authors report the case of a 20-year-old man who presented with a de novo episode of hypomania subsequent to the initiation of quinacrine for treatment resistant giardiasis. " 12/01/1999 - "Re: Letter on quinacrine for treatment of Giardiasis--J Travel Med 1998;5:228." 12/01/1998 - "Quinacrine for treatment of giardiasis." 09/21/1991 - "[Combined oral and endoscopic mepacrine therapy in therapy-resistant symptomatic giardiasis]."

Related Drugs and Biologics

1.	Quinacrine (Mepacrine)
2.	Chloroquine (Aralen)
3.	Quinine (Quinson)
4.	Antimalarials (Antimalarial Agents)
5.	Metronidazole (Metric)
6.	4- ((4- Fluoro- 2- methyl- 1H- indol- 5- yl)oxy)- 6- methoxy- 7- (3- (pyrrolidin- 1- yl)propoxy)quinazoline (AZD2171)
7.	Hydroxychloroquine (Plaquenil)
8.	Chlortetracycline (Aureomycin)
9.	Chlorpromazine (Thorazine)
10.	Indomethacin (Indometacin)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Therapeutics
3.	Thoracotomy
4.	Reproductive Sterilization (Female Sterilization)
5.	Immunotherapy