A spectroscopy based prototype for the noninvasive detection of diabetes from human saliva using nanohybrids acting as nanozyme.
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| Abstract |
The recent prediction of diabetes to be a global pandemic invites a detection strategy preferably non-invasive, and bloodless to manage the disease and the associated complications. Here, we have synthesized chitosan polymer functionalized, organic-inorganic bio-compatible nano-hybrids of Mn3O4 nanoparticles, and characterized it by utilizing several optical methodologies for the structural characterization which shows the Michaelis Menten (MM) kinetics for glucose and alpha-amylase protein (well-known diabetes biomarkers). We have also studied the potentiality for the detection of alpha-amylase in human salivary secretion which is reported to be strongly correlated with uncontrolled hyperglycemia. Finally, we have developed a prototype for the measurement of glucose (LOD of 0.38 mg/dL, LOQ of 1.15 mg/dL) and HbA1c (LOD of 0.15% and LOQ of 0.45%) utilizing the basic knowledge in the study for the detection of uncontrolled hyperglycemia at the point-of-care. With the limited number of clinical trials, we have explored the potential of our work in combating the diabetic pandemic across the globe in near future.
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| Authors | Lopamudra Roy, Susmita Mondal, Neha Bhattacharyya, Ria Ghosh, Amrita Banerjee, Soumendra Singh, Arpita Chattopadhyay, Saleh A Ahmed, Rabab S Jassas, Munirah M Al-Rooqi, Ziad Moussa, Ismail I Althagafi, Debasish Bhattacharya, Kallol Bhattacharya, Asim Kumar Mallick, Samir Kumar Pal |
| Journal | Scientific reports (Sci Rep) Vol. 13 Issue 1 Pg. 17306 (10 12 2023) ISSN: 2045-2322 [Electronic] England |
| PMID | 37828100 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
| Copyright | © 2023. Springer Nature Limited. |
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