alpha-Amylases

Enzymes that catalyze the endohydrolysis of 1,4-alpha-glycosidic linkages in STARCH; GLYCOGEN; and related POLYSACCHARIDES and OLIGOSACCHARIDES containing 3 or more 1,4-alpha-linked D-glucose units.

Also Known As:

Alpha-Amylase Bayer; Maxilase; Mégamylase; alpha-1,4-D-Glucanglucanohydrolase; Alpha Amylase Bayer; AlphaAmylase Bayer; Taka Amylase A; TakaAmylase A; alpha 1,4 D Glucanglucanohydrolase; alpha Amylase; alpha Amylases; Taka-Amylase A; alpha-Amylase; 1,4-alpha-D-Glucan glucanohydrolase

Networked: 504 relevant articles (7 outcomes, 51 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 155591
  - Hydrolases: 2206
    - Glycoside Hydrolases: 890
      - Amylases: 6652
        alpha-Amylases: 504
        Salivary alpha-Amylases: 128
        Pancreatic alpha-Amylases: 26
        Dermatophagoides pteronyssinus antigen p 4: 3
        amyl-1-18 octadecapeptide
        Arabidopsis BE1 protein
        Bacillus licheniformis alpha-amylase
        Bifidobacterium longum BiLA protein
        glycosylated alpha-amylase
        Hordeum vulgare AMY1.2 protein
        Pseudoalteromonas haloplanktis alpha-amylase carboxy terminal propeptide
        S pombe AAH3 protein
        Sulfolobus solfataricus trehalosyl dextrin-forming enzyme
        termamyl

Experts

1.	Nater, Urs M: 9 articles (01/2022 - 04/2006)
2.	Shetty, Kalidas: 7 articles (06/2010 - 01/2006)
3.	Apostolidis, Emmanouil: 5 articles (06/2010 - 06/2008)
4.	Kwon, Young-In: 5 articles (06/2010 - 01/2006)
5.	Doerr, Johanna M: 4 articles (01/2022 - 09/2015)
6.	Strahler, Jana: 4 articles (01/2017 - 09/2015)
7.	Duncan, Ruth: 4 articles (06/2010 - 04/2008)
8.	Lajolo, Franco Maria: 4 articles (12/2009 - 06/2008)
9.	López-Martínez, María José: 3 articles (08/2023 - 07/2023)
10.	Fischer, Susanne: 3 articles (01/2022 - 01/2016)

Related Diseases

1.	Hyperglycemia 10/12/2023 - "We have also studied the potentiality for the detection of alpha-amylase in human salivary secretion which is reported to be strongly correlated with uncontrolled hyperglycemia. " 01/01/2022 - "Alpha-amylase is widely exploited as a drug target for preventing postprandial hyperglycemia in diabetes and other metabolic diseases. " 01/01/2010 - "Flavonoids have been reported as mammalian alpha-amylase inhibitors, a property which could be useful in the management of postprandial hyperglycemia in diabetes and related disorders. " 07/01/2015 - "The present study seeks an alternative drug that can regulate the hyperglycemia by down-regulating alpha-glucosidase and alpha-amylase activity by molecular docking approach to screen the hyperglycemia antagonist against alpha-glucosidase and alpha-amylase activities from the 47 natural compounds. " 01/08/2021 - "The in vitro assays demonstrated that the inhibition of alpha-amylase and alpha-glucosidase might be one of the mechanisms of action exhibited by the extract of this plant to control and prevent postprandial hyperglycemia. "
2.	Hypersensitivity (Allergy) 01/01/2005 - "The aim of the study was to evaluate the prevalence, incidence and risk factors of hypersensitivity to alpha-amylase as well as to identify allergy-related clinical symptoms in apprentice bakers. " 01/01/2022 - "Alpha-amylase as the culprit in an occupational mealworm allergy case." 01/01/2015 - "Sensitization to flour or fungal alpha-amylase is a prerequisite for the development of respiratory allergy in bakers. " 01/01/2005 - "The incidence of allergy to alpha-amylase increases with increasing duration of exposure. " 01/01/2005 - "Generally, 28 (9.8%) apprentices showed hypersensitivity to alpha-amylase after two years of occupational exposure. "
3.	Body Weight (Weight, Body) 05/01/1985 - "[Studies on effects of alpha-amylase inhibitor-X-2 substance on body weight (the second report)]." 04/20/2018 - "The aim of this meta-analysis was to examine the evidence for the effectiveness of a proprietary alpha-amylase inhibitor from white bean (Phaseolus vulgaris L.) supplementation interventions in humans on modification of body weight and fat mass. " 10/14/2009 - "vulgaris dry extract to reduce food intake, body weight, and glycemia in rats may be due to (a) inhibition of alpha-amylase, (b) stimulation of CCK release from the intestinal brush border cells, and/or (c) interference with the central mechanism(s) regulating appetite, food intake, and food palatability." 12/01/2005 - "Twenty-four multiparous Holstein cows [body weight, 759 kg (SD = 30 kg); body condition score, 3.2 (SD = 0.13)] were used in a randomized complete block design to determine the effect of feeding alpha-amylase during the transition period on rumen fermentation, key metabolic indicators, and lactation performance. " 03/01/1989 - "1. The extent of utilization of alpha-amylase (EC 3.2.1.1)-resistant retrograded starches in vivo was assessed in male Wistar rats (about 100 g body-weight). "
4.	Type 2 Diabetes Mellitus (MODY) 01/01/2020 - "An Insight of Alpha-amylase Inhibitors as a Valuable Tool in the Management of Type 2 Diabetes Mellitus." 04/01/2010 - "Because of their fiber content and an alpha-amylase inhibitory effect, beans might be more useful as food components in preventing or ameliorating type 2 diabetes." 01/01/2007 - "[Inhibitors of alpha-amylase from plants--a possibility to treat diabetes mellitus type II by phytotherapy?]." 12/01/2022 - "This study was designed to elucidate the key compounds of asafoetida as potential anti alpha amylase and alpha glucosidase inhibitory role in curing the Type 2 Diabetes Mellites. " 07/15/2022 - "betle were screened to investigate the inhibitory action of alpha-amylase and alpha-glucosidase against type 2 diabetes through molecular docking, molecular dynamics simulation, and ADMET (absorption, distribution, metabolism, excretion, and toxicity) analysis. "
5.	Hypoxia (Hypoxemia) 01/01/2002 - "Membrane integrity of the pancreatic cells was improved, as evidenced by the decrease of plasma alpha-amylase during the time-course study of chronic hypoxia. " 01/01/2016 - "Circadian variation of salivary immunoglobin A, alpha-amylase activity and mood in response to repeated double-poling sprints in hypoxia." 01/25/2006 - "However, steeping conditions affected the rate of recovery from oxygen deficiency, germination rate, and onset of alpha-amylase production. " 01/01/2003 - "The striking difference in the ability to produce alpha-amylase when comparing the anoxia-tolerant rice (Oryza sativa L.) grains with grains of other cereals is not easily explained. " 08/01/2000 - "The significance of alpha-amylase under anoxia stress in tolerant rhizomes (Acorus calamus L.) and non-tolerant tubers (Solanum tuberosum l., var. Désirée)."

Related Drugs and Biologics

1.	alpha-Glucosidases (Acid Maltase)
2.	Enzymes
3.	Antioxidants
4.	Isoenzymes
5.	Blood Glucose (Blood Sugar)
6.	Glucosidases
7.	Flavonoids
8.	Allergens
9.	Glycogen
10.	Creatinine

Related Therapies and Procedures

1.	Therapeutics
2.	Glycemic Control
3.	Fluid Therapy (Oral Rehydration Therapy)
4.	Radiotherapy
5.	Oral Surgery (Maxillofacial Surgery)