[Effect of preparations with antihypoxic properties on ischemic damage to the myocardium].

Abstract

In the experiments on the anesthesized cats sodium hydroxybutyrate and piracetam, in contrast to glyo-6, have been shown to slow down the growth rate of creatine phosphokinase activity in the blood of the coronary sinus during 60-min occlusion of the coronary artery. At the same time, in the experiments on rats with 3-day myocardial infarction GABA derivatives like glyo-6 failed to influence the final size of cardiac necrosis. It may be concluded that anti-ischemic action of some drugs may be expressed only in the reduction of the rate of ischemic lesion development in the heart, but not in the limitation of the infarction size.

• Authors: I B Tsorin, G G Chichkanov
• Journal: Biulleten' eksperimental'noi biologii i meditsiny (Biull Eksp Biol Med) Vol. 102 Issue 11 Pg. 585-7 (Nov 1986) ISSN: 0365-9615 [Print] Russia (Federation)
• Vernacular Title: Deĭstvie preparatov s antigipoksicheskimi svoĭstvami na ishemicheskoe povrezhdenie miokarda.
• PMID: 3779087 (Publication Type: Journal Article)

Chemical References

• pyridoxilate
• Sodium Oxybate
• Pyridoxine
• Piracetam

Topics

• Animals
• Cats
• Hypoxia (drug therapy)
• Male
• Myocardial Infarction (drug therapy)
• Piracetam (therapeutic use)
• Pyridoxine (analogs & derivatives, therapeutic use)
• Rats
• Sodium Oxybate (therapeutic use)