Exploring the synergistic pharmacological mechanism of Huoxiang Drink against irritable bowel syndrome by integrated data mining and network pharmacology.

Abstract

Irritable bowel syndrome (IBS) is the most common functional gastrointestinal disorder, characterized by abdominal pain, bloating, and changes in bowel habits. Huoxiang Drink (HD), derived from traditional Chinese medicine, has been reported to effectively treat digestive disorders caused by external cold and internal dampness. However, the pharmaceutical targets and mechanisms for HD against IBS remain unclear. Data mining, bioinformatics analysis, and network pharmacology were employed to explore the potential pharmacological mechanisms of HD against IBS. In this study, we screened 50 core targets to investigate the pharmacological mechanisms of HD against IBS. Enrichment analysis revealed that HD may participate in various signaling pathways, especially the inflammation-related tumor necrosis factor, signaling pathway and hypoxia-inducible factor signaling pathway. Molecular docking results confirmed that MOL000098 (Quercetin), MOL000006 (Luteolin), MOL005828 (Nobiletin), MOL005916 (Irisolidone), and MOL004328 (Naringenin), as key active ingredients in HD, bound to core targets (tumor protein P53, tumor necrosis factor, matrix metalloproteinases 9, and vascular endothelial growth factor-A) for topical treatment of IBS. This study suggested that HD offered a potential therapeutic strategy against IBS. Our findings may facilitate the efficient screening of active ingredients in HD and provide a theoretical basis for further validating the clinical therapeutic effects of HD on treating IBS.

• Authors: Ruo-Hui Wang, Yi-Ke Lin, Hong-Kai Xie, Hui Li, Mu Li, Dong He
• Journal: Medicine (Medicine (Baltimore)) Vol. 102 Issue 39 Pg. e35220 (Sep 29 2023) ISSN: 1536-5964 [Electronic] United States
• PMID: 37773835 (Publication Type: Journal Article)
• Copyright: Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.

Chemical References

• Vascular Endothelial Growth Factor A
• Tumor Necrosis Factors
• Drugs, Chinese Herbal

Topics

• Humans
• Irritable Bowel Syndrome (drug therapy)
• Network Pharmacology
• Vascular Endothelial Growth Factor A
• Molecular Docking Simulation
• Data Mining
• Tumor Necrosis Factors
• Drugs, Chinese Herbal (pharmacology, therapeutic use)
• Medicine, Chinese Traditional