Irritable Bowel Syndrome (Syndrome, Irritable Bowel)

A disorder with chronic or recurrent colonic symptoms without a clearcut etiology. This condition is characterized by chronic or recurrent ABDOMINAL PAIN, bloating, MUCUS in FECES, and an erratic disturbance of DEFECATION.

Also Known As:

Networked: 2510 relevant articles (269 outcomes, 426 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Constipation
2.	Diarrhea
3.	Pain (Aches)
4.	Abdominal Pain (Pain, Abdominal)
5.	Inflammatory Bowel Diseases (Inflammatory Bowel Disease)

Experts

1.	Camilleri, Michael: 37 articles (08/2015 - 08/2002)
2.	Zinsmeister, Alan R: 24 articles (10/2014 - 03/2003)
3.	Pimentel, Mark: 21 articles (06/2014 - 12/2002)
4.	Quigley, Eamonn M M: 20 articles (04/2015 - 06/2005)
5.	Ford, Alexander C: 19 articles (08/2015 - 01/2008)
6.	Chey, William D: 19 articles (11/2012 - 01/2003)
7.	Camilleri, M: 18 articles (03/2015 - 03/2000)
8.	Dinan, Timothy G: 17 articles (04/2015 - 02/2006)
9.	Talley, Nicholas J: 16 articles (06/2014 - 01/2004)
10.	Whorwell, P J: 15 articles (11/2009 - 06/2000)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Irritable Bowel Syndrome:

1.	tegaserod (Zelnorm)FDA Link 04/01/2005 - "Tegaserod is safe, well tolerated and effective in the treatment of patients with non-diarrhoea irritable bowel syndrome." 08/01/2002 - "Clinical trials show that tegaserod is effective and safe in the treatment of patients with irritable bowel syndrome. " 12/01/2004 - "Tegaserod has been safely employed in clinical trials where it has demonstrated efficacy in normalizing intestinal function, thereby improving irritable bowel syndrome symptoms." 04/01/2010 - "Comments on tegaserod trial on irritable bowel syndrome." 07/01/2007 - "Economic evaluation of tegaserod vs. placebo in the treatment of patients with irritable bowel syndrome: an analysis of the TENOR study."
2.	alosetron (Lotronex)FDA Link 06/01/2002 - "The third report of two placebo-controlled studies indicated significant improvement with alosetron on most domains of Irritable Bowel Syndrome Quality of Life Questionnaire. " 08/01/2005 - "Alosetron hydrochloride (Lotronex, GlaxoSmithKline, Inc) is a safe and effective agent for selective patients with severe irritable bowel syndrome when prescribed as recommended. " 02/01/2003 - "Efficacy of alosetron in irritable bowel syndrome: a meta-analysis of randomized controlled trials." 01/01/2000 - "A double-blind, randomized, placebo-controlled dose-ranging study to evaluate the efficacy of alosetron in the treatment of irritable bowel syndrome." 09/01/1998 - "Alosetron increases the compliance of the colon to distension, and could thereby contribute to changes in perception of colonic distension and improvement in the symptoms of irritable bowel syndrome."
3.	rifaximin (L 105)FDA Link 07/01/2014 - "Clinical studies indicate that rifaximin is beneficial in treating irritable bowel syndrome (IBS). " 05/17/2005 - "Future studies should evaluate whether rifaximin is effective in preventing postinfectious irritable bowel syndrome." 06/01/2012 - "Sequential treatment with rifaximin/probiotics seems to be effective for symptom and fermentative profile improvement in irritable bowel syndrome patients." 03/01/2009 - "Therefore, rifaximin may be useful in the treatment of gastrointestinal disorders associated with altered bacterial flora, including irritable bowel syndrome (IBS) and small intestinal bacterial overgrowth (SIBO). " 09/01/2015 - "Multiple data were presented on the long-term efficacy of rifaximin therapy in patients with irritable bowel syndrome and diarrhoea. "
4.	Serotonin (5 Hydroxytryptamine)IBA 06/01/2011 - "5-Hydroxytryptamine (5-HT)3 receptor (5-HT3R) antagonists are effective in treating patients with irritable bowel syndrome (IBS) and have anxiolytic effects. " 11/01/2009 - "Studies of serotonin reuptake transporter (SERT-P) polymorphism and irritable bowel syndrome (IBS) have shown diverse results among different populations, which might be due to racial and ethnic difference. " 11/01/1999 - "Pre-clinical studies indicate that the 5-hydroxytryptamine (5-HT)4 receptor may be involved in the pathophysiology of irritable bowel syndrome and that antagonism of this receptor may be an effective therapeutic strategy. " 11/26/2015 - "5-Hydroxytryptamine (5-HT) released from colonic mucosal enterochromaffin (EC) cells is a major signaling molecule, which participates in the pathophysiological regulation of colonic functions in gut disorder including irritable bowel syndrome (IBS), but the endogenous modulator system for the 5-HT release is not yet well elucidated. " 08/01/2015 - "The expression of hepatic transporters was assessed using the Western-blot technique in a 2,4,6-trinitrobenzenesulfonic-acid-induced rat model of post-infectious irritable bowel syndrome (PI-IBS), in which serum levels of 5-HT were significantly elevated. "
5.	Antidepressive Agents (Antidepressants)IBA 12/01/2004 - "Antidepressants can be beneficial for irritable bowel syndrome with diarrhoea patients with severe symptoms. " 02/01/2003 - "Psychotherapy and antidepressants are effective in patients with severe irritable bowel syndrome (IBS), but the cost-effectiveness of either treatment in routine practice has not been established. " 03/01/2009 - "Efficacy of antidepressants and psychological therapies in irritable bowel syndrome: systematic review and meta-analysis." 01/01/2008 - "The efficacy of antidepressants in irritable bowel syndrome (IBS) is controversial. " 01/01/2015 - "We searched MEDLINE, EMBASE, Scopus and The Cochrane Library for randomized controlled trials investigating the efficacy and safety of antidepressants in the treatment of irritable bowel syndrome. "
6.	octylonium (otilonium bromide)IBA 01/01/2012 - "Is Otilonium Bromide Really Effective for Treating Asian Patients With Irritable Bowel Syndrome?: Author's Reply." 01/01/2012 - "Is otilonium bromide really effective for treating asian patients with irritable bowel syndrome?" 10/01/2011 - "Is otilonium bromide globally effective in irritable bowel syndrome?" 10/01/1998 - "To evaluate the efficacy of otilonium bromide, a spasmolytic agent, in the treatment of irritable bowel syndrome using modern and validated diagnostic criteria. " 09/14/2014 - "Otilonium bromide in irritable bowel syndrome: a dose-ranging randomized double-blind placebo-controlled trial."
7.	TrimebutineIBA 06/25/2010 - "Trimebutine maleate was effective in reducing the colonic muscle hypercontractility of postinfectious irritable bowel syndrome mice. " 01/01/2006 - "Trimebutine improved symptoms and psychological adjustment to illness in irritable bowel syndrome in comparison with placebo." 06/25/2010 - "The aim of this study was to investigate the effectiveness of trimebutine maleate on modulating colonic hypercontractility in a mouse model of postinfectious irritable bowel syndrome. " 10/01/1980 - "Double blind trial of trimebutine in the irritable bowel syndrome." 01/01/1980 - "A three-part controlled study of trimebutine in the treatment of irritable colon syndrome."
8.	linaclotideIBA 09/01/2013 - "Linaclotide for treatment of irritable bowel syndrome--the view of European regulators." 12/01/2011 - "To review the pharmacology, pharmacokinetics, efficacy, and safety of linaclotide for irritable bowel syndrome (IBS). " 12/01/2011 - "Linaclotide: a novel approach to the treatment of irritable bowel syndrome." 07/01/2013 - "To conclude, linaclotide has a safety and efficacy profile that, from a clinical perspective, warrants its use for patients meeting irritable bowel syndrome and constipation criteria, with significant symptoms that cannot be relieved with other less specific measures. " 11/01/2013 - "Linaclotide: new mechanisms and new promise for treatment in constipation and irritable bowel syndrome."
9.	peppermint oilIBA 06/01/2007 - "With peppermint oil at T(4) and at T(8) compared with T(0) a statistically significant reduction of the total irritable bowel syndrome symptoms score was found (T(0): 2.19+/-0.13, T(4): 1.07+/-0.10*, T(8): 1.60+/-0.10*, *P<0.01 compared with T(0), mean+/-S.E.M.), while no change was found with the placebo. " 04/01/2007 - "Recent evidence suggests that enteric-coated peppermint oil may be effective in relieving some of the symptoms of irritable bowel syndrome. " 12/15/2005 - "Herbal therapies such as peppermint oil also may be effective in the treatment of irritable bowel syndrome. " 07/01/2014 - "The aim of this study was to assess the efficacy and safety of enteric-coated peppermint oil capsules compared with placebo for the treatment of active irritable bowel syndrome (IBS). " 06/01/2007 - "Peppermint oil (Mintoil) in the treatment of irritable bowel syndrome: a prospective double blind placebo-controlled randomized trial."
10.	lubiprostoneFDA Link 01/01/2009 - "A multi-center study of patients with IBS-C found that 8 microg of lubiprostone twice-daily improved both global and individual symptoms of irritable bowel syndrome. " 06/01/2011 - "Efficacy and safety of oral lubiprostone in constipated patients with or without irritable bowel syndrome: a randomized, placebo-controlled and dose-finding study." 02/01/2015 - "Long-term administration of lubiprostone significantly increased scores from the Short-Form health survey and irritable bowel syndrome quality-of-life questionnaire, compared with baseline. " 10/01/2011 - "Lubiprostone does not influence visceral pain thresholds in patients with irritable bowel syndrome." 04/01/2008 - "Lubiprostone significantly improved gastrointestinal symptoms of irritable bowel syndrome with constipation at all doses. "

Therapies and Procedures

1.	Hypnosis (Mesmerism) 08/01/2013 - "[Irritable Bowel Syndrome -- good results with group hypnosis]." 11/07/2008 - "Even though a small number of health professionals are trained in hypnosis and lingering myths and misconceptions associated with this method have hampered its widespread use to treat medical conditions, hypnotherapy has gained relevance as an effective treatment for irritable bowel syndrome not responsive to standard care. " 01/01/2008 - "Clinical hypnosis has been demonstrated to be effective in a number of clinical situations, such as irritable bowel syndrome but, in other areas for which it is commonly employed, such as smoking cessation, the evidence is poor. " 07/01/2006 - "To determine the definite efficacy of hypnosis in the treatment of irritable bowel syndrome. " 06/01/2014 - "To assess the efficacy, tolerability, and safety of hypnosis in adult irritable bowel syndrome by a meta-analysis of randomized controlled trials. "
2.	Drug Therapy (Chemotherapy) 01/01/2009 - "Irritable Bowel Syndrome (IBS) is a common chronic gastrointestinal disorder and the evidence for efficacy of most drug therapies in the treatment of IBS is weak. " 06/01/2005 - "Efficacy of current drug therapies in irritable bowel syndrome: what works and does not work." 04/01/2012 - "Clinical trials of pharmacotherapy for irritable bowel syndrome were eligible for inclusion only if a description of adverse events and the number of patients who discontinued treatment because of adverse events were reported. " 01/01/2015 - "Potential Causes and Present Pharmacotherapy of Irritable Bowel Syndrome: An Overview." 01/01/2015 - "[Pharmacotherapy for irritable bowel syndrome in the context of evidence-based medicine]."
3.	Chinese Traditional Medicine (Traditional Chinese Medicine) 07/01/2006 - "As there is no effective treatment for irritable bowel syndrome (IBS), many patients turn to traditional Chinese medicine (TCM) for possible cure. " 09/01/2004 - "To observe the clinical efficacy of the combination of traditional Chinese medicine and western medicine in treating irritable bowel syndrome (IBS) and the result of intestinal flora regulation. " 04/01/2014 - "This study aimed to examine differences in autonomic responses to stress, pain perception, and the role of negative affect in these responses in individuals with irritable bowel syndrome (IBS) according to Traditional Chinese Medicine (TCM) classifications. " 01/01/2014 - "Traditional Chinese medicine (Shun-Qi-Tong-Xie Granule) for irritable bowel syndrome: study protocol for a randomised controlled trial." 01/01/2013 - "The aims of this study were to evaluate the effect and mechanism of a traditional Chinese medicine formula: Tongxieyaofang (TXYF) on Rats with Post Infectious Irritable Bowel Syndrome (PI-IBS). "
4.	Moxibustion 10/01/2012 - "Clinical randomized controlled trials on treatment of irritable bowel syndrome with acupuncture-moxibustion were collected. " 05/28/2014 - "Acupuncture-moxibustion in treating irritable bowel syndrome: how does it work?" 01/01/2014 - "Mild moxibustion decreases the expression of prokineticin 2 and prokineticin receptor 2 in the colon and spinal cord of rats with irritable bowel syndrome." 01/01/2014 - "To compare differences of clinical therapeutic effect of heat-sensitive moxibustion with different doses for irritable bowel syndrome (IBS). " 01/01/2014 - "[Clinical efficacy observation of heat-sensitive moxibustion with different doses for irritable bowel syndrome]."
5.	Psychology Biofeedback (Biofeedback) 01/01/2013 - "Randomised controlled trial of brief intervention with biofeedback and hypnotherapy in patients with refractory irritable bowel syndrome." 08/01/2011 - "Putting patients first: biofeedback for irritable bowel syndrome patients with dyssynergic defecation." 08/01/2011 - "Outcome of biofeedback therapy in dyssynergic defecation patients with and without irritable bowel syndrome." 01/01/2009 - "In original research are compared results of treatment of irritable bowel syndrome (IBS) by standard technique and treatment with to additional application of the control of a biofeedback. " 08/01/1999 - "[Biofeedback treatment of irritable bowel syndrome]."