[Elucidation of Pathology in Urological Diseases and Creation of New Therapeutics].

Abstract

Global increase in lifestyle-related diseases, such as type 2 diabetes mellitus and hypertension, and infertility rate due to late marriage has become alarming and problematic. Lifestyle-related diseases and infertility rate are strongly linked to urological diseases and are issues that must be resolved to maintain a high QOL. In this review, we elucidated the pathophysiology of urologic diseases, which authors have been researching, and demonstrated the creation of new therapeutic methods for clinical applications. We have clarified the effects of testosterone on the tissue structure and endothelial function of the corpus cavernosum using castrated rats. Additionally, we reported that the administration of testosterone to model rats with type 2 diabetes suppressed the inflammatory response in the corpus cavernosum and improved erectile function in rats. Furthermore, the effect of anti-cancer agents on erectile function was analyzed using the database obtained from the U.S. Food and Drug Administration (FDA) Adverse Event Reporting System (AERS). Finally, we found that the above-mentioned anti-cancer agents had an affected erectile function in rats. Our study may shed light on possible treatment strategies for improving the QOL of patients with erectile dysfunction, including maintenance of erectile function.

• Authors: Tomoya Kataoka
• Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan (Yakugaku Zasshi) Vol. 142 Issue 11 Pg. 1129-1136 ( 2022) ISSN: 1347-5231 [Electronic] Japan
• PMID: 36328441 (Publication Type: Review, English Abstract, Journal Article)

Chemical References

• Testosterone

Topics

• Male
• Humans
• Rats
• Animals
• Erectile Dysfunction (drug therapy, etiology)
• Diabetes Mellitus, Type 2
• Quality of Life
• Rats, Sprague-Dawley
• Testosterone (pharmacology, therapeutic use)
• Urologic Diseases (drug therapy)
• Infertility