Abstract | STUDY OBJECTIVE: DESIGN: Randomized, double-blind, placebo-controlled trial during the first 72 hours of hospitalization. PATIENTS: INTERVENTIONS: MEASUREMENTS AND MAIN RESULTS: The forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) before and after metaproterenol inhalation were measured twice daily by a blinded investigator, who also administered a verbal dyspnea index with a scale of 1 to 10 and questioned patients regarding possible side effects of treatment ( tremor, palpitations, nausea, or vomiting). Arterial blood gas measurements at 72 hours were compared with those obtained on admission. Significant improvements in FEV1 and FVC measured before and after metaproterenol treatment and in dyspnea occurred over time in both treatment groups (p less than 0.05 for all measurements). However, there were no significant differences between the placebo and aminophylline groups in any of the spirometric measurements or the dyspnea indices (p greater than 0.5 in all five analyses). The mean increases (+/- SE) in Po2 of 1.9 (+/- 0.5) kPa with placebo and 1.7 (+/- 0.7) kPa with aminophylline and the mean decreases in PCO2 of 0.5 (+/- 0.4) kPa with placebo and 1.2 (+/- 0.4) kPa with aminophylline were not significantly different (p greater than 0.6 for PO2, p greater than 0.2 for PCO2).(ABSTRACT TRUNCATED AT 400 WORDS)
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Authors | K L Rice, J W Leatherman, P G Duane, L S Snyder, K R Harmon, J Abel, D E Niewoehner |
Journal | Annals of internal medicine
(Ann Intern Med)
Vol. 107
Issue 3
Pg. 305-9
(Sep 1987)
ISSN: 0003-4819 [Print] United States |
PMID | 3619219
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- Aminophylline
- Theophylline
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Topics |
- Acute Disease
- Aged
- Aminophylline
(administration & dosage, metabolism, therapeutic use)
- Double-Blind Method
- Drug Evaluation
- Female
- Forced Expiratory Volume
- Humans
- Lung Diseases, Obstructive
(complications)
- Male
- Middle Aged
- Random Allocation
- Respiratory Insufficiency
(drug therapy, etiology)
- Theophylline
(blood)
- Vital Capacity
(drug effects)
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