Salivary Redox Homeostasis in Human Health and Disease.

Abstract

Homeostasis is a self-regulatory dynamic process that maintains a stable internal environment in the human body. These regulations are essential for the optimal functioning of enzymes necessary for human health. Homeostasis elucidates disrupted mechanisms leading to the development of various pathological conditions caused by oxidative stress. In our work, we discuss redox homeostasis and salivary antioxidant activity during healthy periods and in periods of disease: dental carries, oral cavity cancer, periodontal diseases, cardiovascular diseases, diabetes mellitus, systemic sclerosis, and pancreatitis. The composition of saliva reflects dynamic changes in the organism, which makes it an excellent tool for determining clinically valuable biomarkers. The oral cavity and saliva may form the first line of defense against oxidative stress. Analysis of salivary antioxidants may be helpful as a diagnostic, prognostic, and therapeutic marker of not only oral, but also systemic health.

• Authors: Beáta Čižmárová, Vladimíra Tomečková, Beáta Hubková, Anna Hurajtová, Jana Ohlasová, Anna Birková
• Journal: International journal of molecular sciences (Int J Mol Sci) Vol. 23 Issue 17 (Sep 03 2022) ISSN: 1422-0067 [Electronic] Switzerland
• PMID: 36077473 (Publication Type: Journal Article, Review)

Chemical References

• Antioxidants
• Biomarkers

Topics

• Antioxidants (metabolism)
• Biomarkers (metabolism)
• Homeostasis
• Humans
• Oxidation-Reduction
• Oxidative Stress
• Saliva (metabolism)