Oxidative stress and inflammation caused by 1-tetradecyl-3-methylimidazolium tetrafluoroborate in rat livers.

Abstract

The purpose of this study was to elucidate the mechanism underlying toxicity in the livers of male and female rats after treatment with 1-tetradecyl-3-methylimidazolium tetrafluoroborate ([C14mim]BF4, 0 [control], 12.5, 25, or 50 mg/kg) for 90 days. The results showed that [C14mim]BF4 exposure led to a high level of ROS and MDA in rat livers and the lower expression of Nrf2 and its downstream related antioxidant proteins. In addition, the expression of NF-κB p65 and the levels of inflammatory cytokines were upregulated in exposure groups rats' liver. After 30 days of cessation of exposure, the liver injury of rats in the 50 mg/kg exposure group was alleviated, and the above indicators were improved to varying degrees. The paper shows that [C14mim]BF4 could damage rat liver through oxidative stress and inflammatory pathway.

• Authors: Huafei Yuan, Feng Xu, Xingxing Tian, Haiyan Wei, Rui Zhang, Yueyue Ge, Hongmei Xu
• Journal: Environmental science and pollution research international (Environ Sci Pollut Res Int) Vol. 29 Issue 57 Pg. 86680-86691 (Dec 2022) ISSN: 1614-7499 [Electronic] Germany
• PMID: 35799001 (Publication Type: Journal Article)
• Copyright: © 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

Chemical References

• 1-tetradecyl-3-methylimidazolium
• Reactive Oxygen Species
• NF-E2-Related Factor 2
• NF-kappa B

Topics

• Male
• Female
• Animals
• Rats
• Reactive Oxygen Species (metabolism)
• Oxidative Stress
• NF-E2-Related Factor 2 (metabolism)
• Inflammation (chemically induced, metabolism)
• Liver (metabolism)
• NF-kappa B (metabolism)