The role of NLRP1 and NLRP3 inflammasomes in the etiopathogeneses of pityriasis lichenoides chronica and mycosis fungoides: an immunohistochemical study.

Abstract

Mycosis fungoides (MF) is the most common subtype of primary cutaneous T cell lymphomas, whereas pityriasis lichenoides chronica (PLC) is a chronic inflammatory skin disorder. The inflammasome is a part of the natural immune system which has a multimeric structure consisting of the receptor, adaptor and effector protein that show specificity for various ligands or activators. After the activation of the inflammasome complex, caspase 1 becomes activated which subsequently triggers interleukin-18 (IL-18) and interleukin-1β (IL-1β) production. In our study we aimed to examine the roles of nucleotide-binding oligomerization domain-like receptor containing pyrin domain 1 (NLRP1) and nucleotide-binding oligomerization domain-like receptor containing pyrin domain (NLRP3) inflammasomes in the etiopathogeneses of PLC and MF. NLRP1, NLRP3, caspase 1, IL-18 and IL-1β levels were examined and compared immunohistochemically in the skin biopsies belonging to 16 control patients; 16 PLC cases, 12 cases with stage 1 MF and 12 cases with other stages of MF (stage 2-4). In the paired comparisons of NLRP1, stage 2-4 MF group and PLC group were shown to have increased levels of NLRP1 expression compared to the control group. IL-1β was also expressed at statistically significantly higher levels in each of the stage 1 MF, stage 2-4 MF and PLC groups compared to the control group. In the paired comparisons of caspase 1 and IL-18, it was found that stage 1 MF, stage 2-4 MF and PLC groups had increased levels of expression compared to the control group. Our findings suggest that the NLRP1 inflammasome pathway might play a role in the etiopathogenesis and progression of PLC and MF.

• Authors: Ecem Bostan, Ozay Gokoz, Nilgun Atakan
• Journal: Archives of dermatological research (Arch Dermatol Res) Vol. 315 Issue 2 Pg. 231-239 (Mar 2023) ISSN: 1432-069X [Electronic] Germany
• PMID: 35776169 (Publication Type: Journal Article)
• Copyright: © 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

Chemical References

• Inflammasomes
• NLR Family, Pyrin Domain-Containing 3 Protein
• Interleukin-18
• Caspase 1
• Adaptor Proteins, Signal Transducing
• Apoptosis Regulatory Proteins
• Carrier Proteins
• Nucleotides
• Interleukin-1beta
• NLRP1 protein, human
• NLR Proteins

Topics

• Humans
• Inflammasomes (metabolism)
• NLR Family, Pyrin Domain-Containing 3 Protein (metabolism)
• Interleukin-18 (metabolism)
• Pityriasis Lichenoides
• Caspase 1 (metabolism)
• Adaptor Proteins, Signal Transducing (metabolism)
• Apoptosis Regulatory Proteins (metabolism)
• Mycosis Fungoides
• Carrier Proteins
• Skin Neoplasms
• Nucleotides (metabolism)
• Interleukin-1beta
• NLR Proteins (metabolism)