Abstract | Background: Methods: This cross-sectional study was performed with a sample of 1,947 hospitalized patients with T2DM. Carotid intima-media thickness and carotid artery plaques were measured via Doppler ultrasound. Results:
Uric acid levels were negatively associated with HbA1C, eGFR, and HDL-C (all P < 0.001) and positively associated with WBC, BMI, ACR, creatinine, total cholesterol, triglycerides, LDL-C, systolic blood pressure, and diastolic blood pressure (all P < 0.001). After adjusting for multiple potential confounders, the risks were substantially higher for MetS in the highest quartile of SUA levels (odds ratio: 2.91, 95% confidence interval: 1.54-5.51, P = 0.003 for trend) than in the lowest quartile of SUA levels. Furthermore, a significant increase was observed in the prevalence of overweight/ obesity, hypertension, and dyslipidemia across the SUA quartiles independent of confounders. However, no significant association was found between SUA quartile with the presence of carotid atherosclerosis. Conclusions: In patients with T2DM, SUA levels were closely associated with MetS and its components but not with carotid atherosclerosis.
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Authors | Wei Li, Yan Wang, Shengrong Ouyang, Mengdi Li, Rui Liu, Yuqi Zhang, Xiaojun Liu, Tianfang Li, Shengyun Liu |
Journal | Frontiers in endocrinology
(Front Endocrinol (Lausanne))
Vol. 13
Pg. 890305
( 2022)
ISSN: 1664-2392 [Print] Switzerland |
PMID | 35769075
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2022 Li, Wang, Ouyang, Li, Liu, Zhang, Liu, Li and Liu. |
Chemical References |
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Topics |
- Carotid Artery Diseases
(epidemiology, etiology)
- Carotid Intima-Media Thickness
- Cross-Sectional Studies
- Diabetes Mellitus, Type 2
(complications)
- Humans
- Metabolic Syndrome
(complications, epidemiology)
- Uric Acid
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