Therapeutic Effect of Acer tegmentosum Maxim Twig Extract in Bile Duct Ligation-Induced Acute Cholestasis in Mice.

Abstract

Cholestatic liver disease, or cholestasis, is a condition characterized by liver inflammation and fibrosis following a bile duct obstruction and an intrahepatic accumulation of bile acids. Inhibiting inflammation is a promising therapeutic strategy for cholestatic liver diseases. Acer tegmentosum Maxim extract (ATE) is best known for its anti-inflammatory and antioxidative properties. In this study, we investigated the effects of ATE on liver injury and fibrosis in mice with bile duct ligation (BDL)-induced cholestasis through analysis of gene expression, cytokines, and histological examination. Oral administration of ATE (20 or 50 mg/kg) for 14 days significantly attenuated hepatocellular necrosis compared to vehicle-treated BDL mice, which was accompanied by the reduced level of serum bile acids and bilirubin. We determined that ATE treatment reduced liver inflammation, oxidative stress, and fibrosis. These beneficial effects of ATE were concurrent with the decreased expression of genes involved in the NF-κB pathway, suggesting that the anti-inflammatory effect of ATE could be a possible mechanism against cholestasis-associated liver injury. Our findings substantiate ATE's role as an alternative therapeutic agent for cholestasis-induced liver injury and fibrosis.

• Authors: Ui-Jin Bae, Byung-Hyun Park, Min Kyung Cho, Eun Ju Bae
• Journal: Journal of medicinal food (J Med Food) Vol. 25 Issue 6 Pg. 652-659 (Jun 2022) ISSN: 1557-7600 [Electronic] United States
• PMID: 35708629 (Publication Type: Journal Article)

Chemical References

• Anti-Inflammatory Agents
• Bile Acids and Salts
• Plant Extracts

Topics

• Acer
• Animals
• Anti-Inflammatory Agents (metabolism, pharmacology, therapeutic use)
• Bile Acids and Salts (metabolism, pharmacology, therapeutic use)
• Bile Ducts (metabolism, surgery)
• Cholestasis (drug therapy, metabolism, pathology)
• Fibrosis
• Hepatitis (complications, drug therapy, pathology)
• Inflammation (drug therapy)
• Liver (metabolism)
• Liver Cirrhosis (drug therapy, etiology)
• Mice
• Plant Extracts (pharmacology)