The effects of
hypertension on long-term outcomes according to glycemic status in patients with acute
myocardial infarction (AMI) after successful implantation of newer-generation
drug-eluting stents (DES) have not been fully investigated. In this retrospective cohort study, a total of 11,911 patients were classified into 6 groups according to their glycemic status and presence or absence of
hypertension. The major outcome was
major adverse cardiac events (
MACE), defined as all-cause death, recurrent
myocardial infarction (Re-MI), or any revascularization. In patients without
hypertension, the major outcomes were similar between the normoglycemia and
prediabetes groups. However,
MACE, all-cause
death, cardiac death (CD), Re-MI rates were higher in patients with
type 2 diabetes mellitus (T2DM) than in normoglycemic patients. Additionally, Re-MI was higher in patients with T2DM than in prediabetic patients. In patients with
hypertension, although the major outcomes were similar between the
prediabetes and T2DM groups, in both the
prediabetes and T2DM groups,
MACE, all-cause death, and CD rates were higher than those in the normoglycemia group. During a 2-year follow-up, the comparable harmful effects of
hypertension in patients with AMI and
prediabetes or T2DM were observed. Effective blood pressure and
glucose control should be strengthened to reduce mortality in these patients.