Stachydrine derived from fermented rice prevents diet-induced obesity by regulating adipsin and endoplasmic reticulum homeostasis.

Abstract

Makgeolli, a widely consumed traditional alcoholic beverage in Korea, is brewed mainly from rice using Nuruk as a fermentation starter, which contains fungi, yeast, and lactic acid bacteria. Among 58 Makgeolli samples brewed using various Nuruks, we found that one exhibited anti-obesity properties, with stachydrine shown to be responsible for these properties. Stachydrine promotes lipolysis and inhibits lipid accumulation in 3T3-L1 adipocytes; it also reduces weight gain and improves glucose tolerance and insulin resistance in a mouse model. Stachydrine dramatically suppresses adipsin mRNA levels in liver and adipose tissue, whereas serum adipsin levels were elevated in stachydrine-treated mice compared to mice fed a high-fat diet alone. Moreover, stachydrine recovers endoplasmic reticulum homeostasis and regulates adipsin expression. We highlight the potential use of stachydrine as a therapeutic agent for the treatment of obesity and insulin resistance and the use of Makgeolli fermented by Nuruk as a source of novel bioactive compounds.

• Authors: Eunjung Lee, Sunhee Kang, Ae-Ran Lee, Jae Ho Kim, Tae Wan Kim, Jang Eun Lee, Hye Ryun Kim
• Journal: The Journal of nutritional biochemistry (J Nutr Biochem) Vol. 107 Pg. 109036 (09 2022) ISSN: 1873-4847 [Electronic] United States
• PMID: 35533898 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.

Chemical References

• Proline
• Complement Factor D
• stachydrine

Topics

• 3T3-L1 Cells
• Animals
• Complement Factor D (therapeutic use)
• Diet, High-Fat (adverse effects)
• Endoplasmic Reticulum (metabolism)
• Homeostasis
• Insulin Resistance
• Mice
• Mice, Inbred C57BL
• Obesity (etiology, prevention & control)
• Oryza
• Proline (analogs & derivatives)