Abstract | Background: Methods: Results: Pregnant HFD-fed mice displayed significant insulin resistance and dyslipidemia. ITF (3.33 g/kg/day) treatment improved glucose and lipid metabolism disorder parameters in HFD-induced GDM mice and alleviated fat accumulation and glucose intolerance. The alpha diversity of the gut microbial community was increased in ITF mice, while the beta diversity returned to the level of normal chow diet (NCD) mice. Interestingly, Verrucomicrobia, Bifidobacterium, and Akkermansia were obviously enriched, while Dubosiella was obviously lessened after inulin treatment. Further analysis indicated that Dubosiella was positively correlated with markers of glycolipid metabolism disorders, whereas the ITF-supplemented diet partially reversed the changes. Conclusion:
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Authors | Miao Miao, Qing Wang, Xinyan Wang, Chong Fan, Ting Luan, Lina Yan, Yue Zhang, Xin Zeng, Yongmei Dai, Ping Li |
Journal | Frontiers in microbiology
(Front Microbiol)
Vol. 13
Pg. 832151
( 2022)
ISSN: 1664-302X [Print] Switzerland |
PMID | 35495651
(Publication Type: Journal Article)
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Copyright | Copyright © 2022 Miao, Wang, Wang, Fan, Luan, Yan, Zhang, Zeng, Dai and Li. |