Inulin

A starch found in the tubers and roots of many plants. Since it is hydrolyzable to FRUCTOSE, it is classified as a fructosan. It has been used in physiologic investigation for determination of the rate of glomerular function.

Networked: 773 relevant articles (84 outcomes, 110 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Petrovsky, Nikolai: 7 articles (03/2015 - 12/2004)
2.	Cherney, David Z I: 5 articles (01/2015 - 02/2010)
3.	Dubourg, Laurence: 5 articles (04/2014 - 09/2008)
4.	Hinrichs, Wouter L J: 5 articles (11/2013 - 01/2007)
5.	Frijlink, Henderik W: 5 articles (11/2013 - 01/2007)
6.	Seguro, Antonio Carlos: 5 articles (08/2012 - 10/2002)
7.	Mutanen, Marja: 5 articles (05/2008 - 10/2002)
8.	Caderni, Giovanna: 5 articles (02/2007 - 11/2002)
9.	Roberfroid, M B: 5 articles (05/2002 - 01/2000)
10.	Matsuo, Seiichi: 4 articles (12/2015 - 12/2010)

Related Diseases

1.	Body Weight (Weight, Body) 05/01/1992 - "Intravenous doses of 23.15 and 92.60 mumol of L-gamma-glutamyl-L-DCVC/kg of body weight induced significant increases in urinary protein output and significant decreases in the clearance of inulin during the 6-hour post-injection period. " 04/27/1997 - "CsA, administered at 15 mg/kg/body weight (BW) subcutaneously for 10 days, caused a decrease in glomerular filtration rate, with inulin clearance of 0.33+/-0.04 vs. 1.11+/-0.06 ml/min/100 g BW (P<0.01 vs. control). " 01/01/1993 - "The total clearance of oxalate was 177 +/- 29 and that for inulin was 30 +/- 5 microliters/min/100 g body weight. " 11/01/1976 - "[3H]Methylated-LH was found to have a renal clearance of 0.17+/-0.03 ml/min/100 g body weight, compared to a value of 0.99+/-0.18 for tritiated inulin. " 08/01/2015 - "Longer intervention trials are required to assess the impact of inulin enriched breads on energy intake and body weight. "
2.	Neoplasms (Cancer) 09/01/2002 - "The results of this study indicate that dietary long-chain inulin suppresses AOM-induced ACF formation, an early preneoplastic marker of colon tumorigenesis in rats, and colon tumors, particularly at the promotion stage." 01/01/2016 - "Structural characterization and anti-tumor effects of an inulin-type fructan from Atractylodes chinensis." 12/01/2015 - "Therefore, we analyzed the performance of GFR equations among patients with cancer whose GFR values were measured by inulin clearance (Cin). " 01/01/2015 - "These data suggest that inulin holds therapeutic potential and is a strong candidate for inclusion among the functional foods used for cancer prevention in both properly nourished and malnourished individuals." 12/01/2010 - "Inulin clearance was measured in 28 patients with cancer. "
3.	Ischemia 01/01/1994 - "Both T4 (10 micrograms/100 g) and T3 (1 and 10 micrograms/100 g) resulted in significant improvement in inulin clearance when compared to ischemia alone, while reverse T3 was without effect. " 09/01/2002 - "Renal clearance studies (inulin) were performed 24 hours after ischemia in 6 Groups (n=6 in each Group) of both Y- and O-rats: control rats (CON), untreated rats with ARF (Groups IRA), and rats with ARF but pretreated with ATO (Groups ATO+IRA). " 09/01/1990 - "Further studies, in uninephrectomized rats, demonstrated that following fifteen minutes of renal ischemia and four hours of reperfusion inulin clearance, FENa+ and cellular morphology were normal. " 05/01/2007 - "Inulin and PAH clearance was determined starting from 6 up to 336 h after ischemia-reperfusion (I/R) injury. " 05/01/2004 - "Inulin clearance (InCl) was performed 48 h after renal ischemia. "
4.	Proteinuria 01/01/2008 - "The prognostic factors GFR_ECC, age, BMI, HOMA and proteinuria had a statistically significant impact on the inulin clearance (the gold standard of the GFR) in our patient population (p < 0.05). " 03/01/1994 - "During LPD, inulin and PAH clearances in CON demonstrated a progressive 25% decline of basal GFR and RPF; on the contrary, in CRF, basal renal function did not change in presence of a significant reduction of proteinuria. " 12/01/1998 - "Study parameters included BP, 24-h proteinuria, GFR, and effective renal plasma flow (ERPF) as determined by inulin and para-aminohippurate clearance. " 12/01/1988 - "After 6 months of study, proteinuria was reduced significantly without reduction in inulin or para-aminohippurate clearance. " 10/01/1997 - "Other parameters measured at baseline included proteinuria and inulin clearance. "
5.	Hypertension (High Blood Pressure) 01/01/1988 - "Glomerular filtration rate (GFR) and renal plasma flow (inulin and para-aminohippurate clearance) were measured in a random sample of 17 normotensive and 20 untreated patients with primary hypertension. " 09/01/1982 - "Hypertension developed after 1 to 2 weeks of the DOC-salt regimen and was always preceded by enlargement of the inulin space and increased plasma and blood volume. " 12/01/1977 - "Extracellular fluid volume determined by a single injection of inulin in men with untreated essential hypertension." 04/01/1960 - "I. Extracellular fluid volume (inulin space) in hypertension." 01/01/2006 - "Results of the study show that enrichment of a diets with inulin in patients with ishemic heart disease and hypertension improved clinic status, antropometric levels, lipid spectrum of blood and immune status. "

Related Drugs and Biologics

1.	Creatinine
2.	p-Aminohippuric Acid (p-Aminohippurate)
3.	oligofructose
4.	hippuric acid
5.	Prebiotics
6.	Sodium
7.	Urea (Carbamide)
8.	Potassium
9.	Cisplatin (Platino)
10.	Iohexol (Omnipaque)

Related Therapies and Procedures

1.	Transplants (Transplant)
2.	Protein-Restricted Diet (Diet, Protein Restricted)
3.	Intravenous Infusions
4.	Transplantation (Transplant Recipients)
5.	Injections