Abstract | AIMS/INTRODUCTION: MATERIALS AND METHODS: The FBG levels of a study population from a cadmium (Cd)-polluted area (n = 250) and an unpolluted area (n = 204), and the metal levels, including magnesium, calcium (Ca), iron (Fe), zinc (Zn), arsenic (As), Cd, copper and lead (Pb) in blood and urine were detected. The study population was divided into a normal fasting glucose group, an IFG group and a diabetes mellitus group on the basis of FBG levels. RESULTS: The IFG rate and diabetes mellitus prevalence were negatively associated with blood Cd and urine Zn levels (IFG rate: odds ratio [OR] 0.780, 95% confidence interval [CI] 0.655-0.928; OR 0.622, 95% CI 0.465-0.831. Diabetes mellitus prevalence: OR 0.506, 95% CI 0.288-0.888; OR 0.609, 95% CI 0.395-0.939), the IFG rate was positively associated with urine Fe levels (OR 1.876, 95% CI 1.290-2.778), and diabetes mellitus prevalence was positively associated with urine Pb and blood Fe levels (OR 1.185, 95% CI 1.022-1.376; OR 1.008, 95% CI 1.001-1.014). A linear negative correlation was observed between FBG levels and blood Cd, and non-linear inverted U-shaped associations were found between FBG levels and Zn, Pb and copper in urine. CONCLUSIONS: This research suggests that multi- metal exposure, especially Cd, Fe, Zn, copper and Pb, is linked to diabetes mellitus, and the interactive effects of multiple metals require further exploration.
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Authors | Jing Zhang, Huanhuan Yin, Xuemei Zhu, Rong Xiang, Yeqiu Miao, Yu Zhang, Yang Song, Jinyao Chen, Lishi Zhang |
Journal | Journal of diabetes investigation
(J Diabetes Investig)
Vol. 13
Issue 8
Pg. 1412-1425
(Aug 2022)
ISSN: 2040-1124 [Electronic] Japan |
PMID | 35340117
(Publication Type: Journal Article)
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Copyright | © 2022 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd. |
Chemical References |
- Blood Glucose
- Cadmium
- Lead
- Copper
- Zinc
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Topics |
- Blood Glucose
- Cadmium
(urine)
- China
(epidemiology)
- Copper
(urine)
- Cross-Sectional Studies
- Diabetes Mellitus
(epidemiology)
- Fasting
- Humans
- Lead
- Prediabetic State
- Zinc
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