Arsenic

A shiny gray element with atomic symbol As, atomic number 33, and atomic weight 75. It occurs throughout the universe, mostly in the form of metallic arsenides. Most forms are toxic. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), arsenic and certain arsenic compounds have been listed as known carcinogens. (From Merck Index, 11th ed)

Networked: 3323 relevant articles (92 outcomes, 543 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Waalkes, Michael P: 62 articles (07/2015 - 02/2002)
2.	Chen, Chien-Jen: 55 articles (01/2015 - 04/2002)
3.	Hsueh, Yu-Mei: 50 articles (01/2015 - 04/2002)
4.	Ahsan, Habibul: 49 articles (09/2015 - 07/2003)
5.	Smith, Allan H: 40 articles (10/2015 - 05/2002)
6.	Chen, Yu: 39 articles (09/2015 - 07/2003)
7.	Parvez, Faruque: 36 articles (11/2015 - 03/2006)
8.	Graziano, Joseph H: 33 articles (11/2015 - 07/2003)
9.	Slavkovich, Vesna: 30 articles (11/2015 - 07/2003)
10.	Karagas, Margaret R: 27 articles (09/2015 - 03/2002)

Related Diseases

1.	Acute Promyelocytic Leukemia 07/01/2008 - "The ancient drug, arsenic, has remarkable efficacy in the treatment of relapsed acute promyelocytic leukemia (APL) and this success has led to exploration of its use in other malignancies. " 02/01/2005 - "Arsenic, a natural substance that has been used as a drug for over 2000 years, has been revived because of its remarkable therapeutic efficacy in patients with acute promyelocytic leukemia (APL). " 02/05/2010 - "Arsenic is ubiquitously present in the environment; it is a known human carcinogen and paradoxically it is also a successful drug for the clinical remission of acute promyelocytic leukemia (APL). " 06/01/2001 - "Arsenic oxide (As2O3) has recently been reported to induce remission in a high percentage of patients with acute promyelocytic leukemia (APL). " 05/01/2013 - "Although arsenic is effective in the treatment of acute promyelocytic leukemia (APL), as a well-known environmental toxicant, the side effects of arsenic treatment and arsenic methylation metabolism of the patients are rarely reported. "
2.	Neoplasms (Cancer) 01/01/1981 - "The chance to induce cancer by medical treatment in dermatology is considered to be very low since arsenic has been eliminated." 08/03/2009 - "In contrast, inorganic arsenic significantly decreased the incidence of tumors in liver (0%) and adrenal glands (0%) of male mice continuously exposed from gestation through one year, as compared to levels in control (30 and 65%, respectively) and gestation only (33 and 55%, respectively) exposed mice. " 06/01/2006 - "However, a five-year follow-up study showed no more significant improvement of skin lesions, while the potential risk of arsenic-induced cancers after cutting off high-arsenic exposure was still uncertain and indefinite. " 07/01/1976 - "Furthermore, a recent trend has been to consider arsenic as beneficial in cancer prevention and in maintaining the health of farm animals, and, perhaps, humans. " 11/01/2003 - "The paradox of arsenic is that it has also a valuable therapeutic efficacy in cancer treatment. "
3.	Body Weight (Weight, Body) 01/01/2007 - "Grasshoppers consumed significantly greater amounts of the frond tissue, produced more fecal pellets and had increased body weight on control plants compared with grasshoppers fed arsenic-treated ferns. " 04/01/2006 - "The Food and Agriculture Organization/World Health Organization (FAO/WHO) provisional tolerable weekly intake (PTWI) values of arsenic in our study were 3.32, 5.75 and 12.9 microg/kg body weight/day from mild, moderate and high arsenic-affected families, respectively, which is higher than the recommended PTWI value of arsenic (2.1 microg/kg body weight/day)." 05/01/2015 - "The maximum dietary risk of exposure to inorganic arsenic through transplanted boro paddy in the present experiment was calculated to be almost 1706% of the provisional tolerable weekly intake for an adult of 60 kg body weight. " 01/01/2015 - "We found that arsenic at dosages of 1, 3, and 10 mg/kg decreased body weight and increased the arsenic content in the brain. " 01/01/2015 - "Arsenic exposure was associated with decreased liver weight but no change in body weight. "
4.	Leukemia 08/01/2014 - "However, after As2O3 biotransformation, the role of arsenic metabolites in the clinical efficacy against leukemia still needs to be elucidated. " 08/01/2010 - "While arsenic is a known carcinogen, recent studies suggest that it is useful as a therapeutic agent for leukemia. " 05/01/2002 - "The findings in this study are reassuring in that leukemia risks were not increased at the concentrations of arsenic in water found in this study. " 04/05/1999 - "These studies establishing RA/arsenic synergy in vivo prompt the use of combined arsenic/RA treatments in APL patients and exemplify how mouse models of human leukemia can be used to design or optimize therapies." 01/01/2016 - "Given that MRP4 is a major contributor to arsenic resistance in vitro, further investigation into the correlation between MRP4 expression and treatment outcome of leukemia patients treated with arsenic-based regimens is warranted. "
5.	Inflammation 01/01/2015 - "In continuation to that the present study has therefore been focused to investigate the protective efficacy of amla in arsenic induced inflammation and immunotoxicity in mice. " 01/01/2015 - "Results of the present study clearly indicate that arsenic induced immunotoxicity linked with inflammation has been significantly protected through simultaneous treatment with arsenic and amla that was due to anti-inflammatory and antioxidant activity of amla. " 06/01/2012 - "However, our study highlighted some hypotheses (sex-specific marker, antioxidant function, arsenic metabolism, and modulation of inflammation processes) that might help to clarify the potential role of GSTO1 in EH pathophysiology." 10/01/2015 - "The connection between arsenic dosage and inflammation-related genes was assessed. " 09/01/2015 - "Recently our group demonstrated that the exposure to arsenic during early childhood or in utero in children was associated with impairment in the lung function and suggested that this adverse effect could be due to a chronic inflammation response to the metalloid. "

Related Drugs and Biologics

1.	arsenic trioxide (Trisenox)
2.	Tretinoin (Retinoic Acid)
3.	sodium arsenite
4.	Iron
5.	Arsenicals (Arsenic Compounds)
6.	Folic Acid (Vitamin M)
7.	Sodium
8.	Curcumin
9.	Quercetin
10.	Succimer (Dimercaptosuccinic Acid)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Renal Dialysis (Hemodialysis)
3.	Chemoprevention
4.	Oral Administration
5.	Intravenous Injections