Abstract |
Neural repair within the central nervous system (CNS) has been extremely challenging due to limited abilities of adult CNS neurons to regenerate, particularly in a highly inflammatory injury environment that is also filled with myelin debris. Spinal cord injury (SCI) is a serious medical condition that often leads to paralysis and currently has no effective treatment. Here we report the construction of a novel biocompatible and biodegradable material, Bio-C, through coating of acid-desalted- collagen (ADC) tube with pre-modified hyaluronic acid, which, after implantation, can elicit quite robust neural regeneration and functional recovery after complete spinal-cord transection with a 2 mm-spinal-cord-segment removal in mice. We combined morphological, electrophysiological, and objective transcriptomic analyses, in addition to behavioral analyses, to demonstrate neural tissue regeneration and functional recovery through the establishment of Bio-C-induced anti-inflammatory, neurogenic, and neurotrophic microenvironment. Through this study, we unveiled the underlying logic for CNS neural repair.
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Authors | Changhong Zheng, Huina Zhang, Yanling Cui, Yuchen Mu, Kun Jiang, Liqiang Zhou, Junbang Wang, Jiping Liu, Yaxuan Deng, Chunxue Zhang, Wenmin Zhu, Kongyan Wu, Yi Eve Sun |
Journal | Pharmaceutics
(Pharmaceutics)
Vol. 14
Issue 3
(Mar 09 2022)
ISSN: 1999-4923 [Print] Switzerland |
PMID | 35335971
(Publication Type: Journal Article)
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