Successful management of feline pemphigus foliaceus with pentoxifylline and topical hydrocortisone aceponate.

Abstract

The treatment regimen for feline pemphigus foliaceus (PF), an autoimmune disease caused by auto-antibodies against proteins of the desmosome junction, usually includes high doses of oral or parenteral immunosuppressive drugs, typically glucocorticoids. This case adds to a growing body of evidence that topical hydrocortisone aceponate is effective for the treatment of feline PF, and demonstrates the practical use of a non-invasive diagnostic method for histopathology when owners refuse a biopsy to support a clinical diagnosis of PF. Finally, this case highlights an international trend of owner-initiated treatment of feline infectious peritonitis (FIP) using unlicensed, unregistered drugs.

• Authors: Stefan Hobi, Julia A Beatty, Jeanine R Sandy, Vanessa R Barrs
• Journal: Veterinary medicine and science (Vet Med Sci) Vol. 8 Issue 3 Pg. 937-944 (05 2022) ISSN: 2053-1095 [Electronic] England
• PMID: 35212177 (Publication Type: Case Reports, Research Support, Non-U.S. Gov't)
• Copyright: © 2022 The Authors. Veterinary Medicine and Science published by John Wiley & Sons Ltd.

Chemical References

• Glucocorticoids
• Immunosuppressive Agents
• hydrocortisone aceponate
• Pentoxifylline
• Hydrocortisone

Topics

• Animals
• Cat Diseases (drug therapy)
• Cats
• Glucocorticoids (therapeutic use)
• Hydrocortisone (analogs & derivatives)
• Immunosuppressive Agents
• Pemphigus (diagnosis, drug therapy, veterinary)
• Pentoxifylline (therapeutic use)