Pemphigus (Pemphigus Vulgaris)

01/01/2015 - "Rituximab is extremely effective in recalcitrant pemphigus, when other treatments fail to control the disease. "
12/01/2014 - "IMPORTANCE B-cell depletion with the anti-CD20 antibody rituximab is highly effective for pemphigus vulgaris (PV) treatment. "
01/01/2014 - "One course of rituximab and treatment of relapses is highly effective and well tolerated in the treatment of refractory pemphigus. "
12/01/2015 - "Complete remission after rituximab therapy in an HIV-positive patient with pemphigus vulgaris."
01/01/2007 - "It is important that clinicians are aware that the response to rituximab in pemphigus may be delayed, and that prolonged treatment may have a good outcome."

10/01/2013 - "Assessment of the rate of long-term complete remission off therapy in patients with pemphigus treated with different regimens including medium- and high-dose corticosteroids."
02/01/2015 - "The main component of the first-line treatment of pemphigus vulgaris is high doses of systemic corticosteroids, but adverse effects of these drugs are frequent and sometimes severe. "
10/01/2009 - "Analysis of the data suggests that MTX may be useful and effective in patients with pemphigus vulgaris, who are corticosteroid dependent or who develop significant complications in relation to corticosteroids. "
01/01/2014 - "Though systemic corticosteroids have been the mainstay of treatment for pemphigus over the years, more recently research has focused on steroid-sparing agents. "
08/01/2014 - "Systemic corticosteroids have long been the mainstay of treatment for pemphigus patients. "

03/01/2009 - "[Prolonged complete clinical remission in patients with severe pemphigus vulgaris after cycles of intravenous cyclophosphamide]."
03/01/2009 - "Five of the 8 patients achieved complete remission of pemphigus lesions after 10 cycles of cyclophosphamide. "
01/01/2012 - "Several pulsed cyclophosphamide regimens have, therefore, been developed and are reported to be effective in severe forms of pemphigus. "
08/01/2013 - "We undertook a randomized, prospective, non-blinded trial to assess the efficacy of cyclophosphamide pulse therapy (CPT) as an adjuvant to oral corticosteroid in pemphigus vulgaris (PV). "
12/01/1992 - "Further studies using larger groups of patients are needed to evaluate the efficacy of pulse intravenous cyclophosphamide in pemphigus vulgaris. "

06/01/1989 - "IgG subclasses were determined in perilesional skin of 13 patients with pemphigus with active disease and of 14 patients in a state of clinical remission. "
06/01/1989 - "Determination of IgG subclasses in patients with pemphigus with active disease and in remission."
03/01/2014 - "This series highlights the punctate or dot-like pattern of intercellular IgG deposition in DIF studies of pemphigus, reviews potential mechanisms and calls attention to this potentially under-recognized phenomenon. "
03/01/2014 - "Intercellular epidermal deposition of immunoglobulin G (IgG) in a continuous net-like or 'chicken wire' pattern is a well-described and diagnostic finding in direct immunofluorescence (DIF) studies of pemphigus. "
02/01/2014 - "The current study aimed to evaluate whether increasing the IgG antibody titer represents a good indicator of the pemphigus recurrence. "

06/15/2013 - "In the present study, treatment methods used for patients suffering from pemphigus vulgaris were not successful in significantly decreasing the circulative autoantibodies levels."
11/01/2010 - "The aim of this study was to determine its expression of desmosomal components and to evaluate its use as a detection tool for circulating autoantibodies in canine pemphigus. "
03/01/2009 - "Although several reports suggest an association between pemphigus and other autoimmune connective tissue disorders, studies that measure non-organ-specific autoantibodies are lacking. "
01/01/2009 - "The aim of the study was to determine the relationship between autoantibodies levels and the extent of both mucosal and skin lesions in 20 patients with pemphigus vulgaris at the time of diagnosis and during follow-up. "
10/01/2007 - "As it is unlikely that desmosomal signaling would occur only in response to pemphigus autoantibodies, these studies suggest that numerous different signaling molecules may play a role in desmosomal homeostasis. "

01/01/2007 - "The main outcome measures were average time to clinical remission, average time to immunologic remission (non-detectable circulating pemphigus vulgaris antibodies), proportion of patients who remained free of clinical relapse within 5 years after discontinuation of therapy, time from treatment discontinuation until first relapse, and incidence of adverse effects. "
01/01/1987 - "The subsets of T-cells in 10 non-treated patients with active pemphigus vulgaris and 5 patients with a long-term steroid maintained remission of the disease were studied using OKT series monoclonal antihuman antibodies. "
10/01/2015 - "The purpose of the present study is to investigate the presence of anti-Dsg3 antibodies in normal Egyptians aiming to determine the reason for the increase in number of patients in Egypt with pemphigus. "
05/01/2006 - "This study suggests that the severity of skin and oral disease in pemphigus is determined by the quantities of Dsg1 and Dsg3 antibodies respectively."
06/01/2005 - "The objective of our study was to investigate the presence of anti-alpha6 integrin antibodies in patients with classical BP. The autoantibody profiles of 30 patients with BP, 10 patients with pemphigus vulgaris, and 20 healthy persons were identified. "

01/01/2014 - "To evaluate anti-desmoglein ELISA (Dsg ELISA) in the follow-up of pemphigus and compare ELISA with direct and indirect immunofluorescence in complete remission (CR). "
03/01/2010 - "To the best of our knowledge there is only one report about salivary desmoglein (Dsg) 1 and 3 enzyme-linked immunosorbent assay (ELISA) in pemphigus vulgaris (PV), whereas several studies have been performed on serum. "
01/01/2006 - "This study 1) validates sequence redundancy to autoproteome as a main factor in shaping desmoglein peptide immunogenicity; 2) offers a molecular mechanicistic basis in analyzing the commonality of autoimmune responses exhibited by the two forms of pemphigus; 3) indicates possible peptide-immunotherapeutical approaches for pemphigus diseases."
01/01/2002 - "This study demonstrates that epidermal desmoglein expression is altered in some cases of pemphigus foliaceus in dogs and suggests that immunohistochemical staining for this protein may be useful in diagnosis."
12/01/2015 - "Loss of Desmoglein Binding Is Not Sufficient for Keratinocyte Dissociation in Pemphigus."

03/01/1987 - "It is concluded that azathioprine-corticosteroid treatment of pemphigus is highly effective and safe; it leads to long-term remissions in most patients and possibly to a cure in some."
01/01/2015 - "She had a history of pemphigus vulgaris maintained in remission with azathioprine, with no evidence of active oral or cutaneous disease at the time of presentation. "
03/01/1987 - "In a prospective long-term study, thirty-seven patients with severe generalized pemphigus vulgaris were treated with a combined corticosteroid-azathioprine regimen. "
09/01/2012 - "We report a case of neutropenic ulceration in a 42-year-old woman receiving azathioprine for pemphigus vulgaris. "
05/01/2012 - "Azathioprine is clinically meaningful for the treatment of pemphigus."

07/01/2012 - "Six (55.6%) of the 11 patients with pemphigus had complete or partial remission and were able to taper their prednisolone. "
08/01/1998 - "With a working diagnosis of pemphigus vulgaris, she was treated successfully with low dosage prednisolone. "
04/01/1999 - "In spite of the fact that prednisolone-based treatment of pemphigus patients has proved to be effective in controlling the disease, some undesirable effects associated with this form of treatment have prompted investigation into other therapeutic approaches. "
11/01/2006 - "Fifty-seven patients with pemphigus vulgaris who were in clinical remission for at least 3 months, while taking prednisolone 5-7.5 mg/day, were recruited retrospectively for the study. "
11/01/2006 - "He received corticosteroid therapy (prednisolone 40 mg/day) and went into a state of temporally remission regarding pemphigus. "

01/01/2010 - "Thus, we may conclude that: (i) the percentage of patients with oropharyngeal pemphigus vulgaris who achieved complete long-lasting clinical remission was very high; (ii) transient lesions that healed within a week were very frequent and had to be actively controlled; (iii) if treated early, most patients had a good clinical response and could achieve a disease- and drug-free clinical remission; (iv) early treatment may prevent extension or progression of disease; (v) there is a possible role for immunosuppressive agents; and (vi) a more favorable course of the disease, in terms of attainment and duration of clinical remission and a better prognosis, seemed to be related to a rapid response to therapy rather than to the initial severity and extent of the disease."
11/01/2003 - "For the treatment of pemphigus, a course of the lowest possible corticosteroid dosage in combination with immunosuppressive agents appears to be effective and less toxic than a high corticosteroid dosage."
11/01/2002 - "Although pemphigus vulgaris is still a life-threatening disease, today it can be successfully treated with a combination of immunosuppressive agents. "
10/12/2015 - "Eliminating possible drug PV/PF triggers/sustainers may alleviate the clinical symptoms and enable the decrease of dose/range of immunosuppressants regardless of pemphigus form."
10/12/2015 - "Drug triggering should be suspected in every case of newly diagnosed or exacerbated pemphigus, as eliminating possible PV/PF triggers/sustainers may alleviate the clinical symptoms and enable the decrease of dose/range of immunosuppressants regardless of pemphigus form. "

04/01/2008 - "Using ELISA against recombinant Dsg3 and Dsg1, to evaluate the efficacy of plasmapheresis in pemphigus. "
03/01/1995 - "Relapses of pemphigus seldom occurred, and the patients stayed in remission 90% (40-100%) (median and ranges) of the plasmapheresis period. "
12/01/2000 - "The objective of this study was to assess the group's experience with plasmapheresis in the treatment of pemphigus vulgaris and report on its utility. "
06/01/1989 - "Indications for future studies on the treatment of pemphigus with plasmapheresis."
06/15/1980 - "[Trials with therapeutic plasmapheresis in pemphigus vulgaris]."

09/01/2013 - "To study the clinical and immunologic characteristics of Indian pemphigus patients before and after treatment. "
12/01/2012 - "Mucosal manifestations of pemphigus vulgaris in ear, nose, and throat; before and after treatment."
08/01/2004 - "Skin lesions of pemphigus foliaceus did not recur for 1.5-6 years after treatment was stopped. "
07/01/2006 - "Improvement of familial benign pemphigus after treatment with pulsed-dye laser: a case report."
11/01/2002 - "We describe a 30-year-old woman with refractory pemphigus vulgaris who experienced a partial remission after treatment with rituximab."

12/01/1992 - "Pemphigus foliaceus treated successfully with plasma exchange."
11/01/1988 - "To determine the potential steroid sparing effect of plasma exchange in pemphigus we enrolled 40 patients in a multicenter randomized study. "
11/01/1988 - "Controlled study of plasma exchange in pemphigus."
03/01/1981 - "Pemphigus vulgaris and plasma exchange: clinical and serologic studies."
07/01/2015 - "Therapeutic Plasma Exchange-A New Dawn in the Treatment of Pemphigus Vulgaris."

07/01/2007 - "Complete remission of drug-resistant Pemphigus vegetans treated by extracorporeal photopheresis."
01/01/1999 - "In drug-resistant PV and pemphigus foliaceus, long-term adjuvant treatment with extracorporeal photochemotherapy (photopheresis, ECP) has been reported to induce remission. "
01/01/1999 - "Seven patients with drug-resistant autoimmune bullous diseases have been referred to the photopheresis center of Jena (3 x PV, 3 x BP, 1 x pemphigus foliaceus). "
03/01/1997 - "Severe pemphigus foliaceus treated with extracorporeal photochemotherapy."
05/01/1992 - "Pemphigus vulgaris treated with photopheresis."

11/01/2015 - "Thoracoscopic thymectomy in a patient with pemphigus."
07/01/2013 - "Extended thymectomy may be an effective therapy for treating patients with pemphigus."
08/01/1984 - "[A case of pemphigus foliaceus after thymectomy]."
07/01/2013 - "Pemphigus with thymoma improved by thymectomy: report of a case."
09/01/1990 - "In some patients pemphigus develops after thymectomy and myasthenia gravis is often associated. "