Cancer is a great challenge facing global public health. Scholars have made plentiful efforts in the research of
cancer therapy, but the results are still not satisfactory. In relevant literature, the role of
miRNA in
cancer has been widely concerned.
MicroRNAs (
miRNAs) are a non-coding, endogenous, single-stranded RNAs that regulate a variety of
biological functions. The abnormal level of miR-30d-5p, a type of
miRNAs, has been associated with various human
tumor types, including
lung cancer,
colorectal cancer,
esophageal cancer,
prostate cancer,
liver cancer,
cervical cancer,
breast cancer and other types of human
tumors. This reflects the vital function of miR-30d-5p in
tumor prognosis. miR-30d-5p can be identified either as an inhibitor hindering the development of, or a promoter accelerating the occurrence of
tumors. In addition, the role of miR-30d-5p in cell proliferation, motility, apoptosis, autophagy,
tumorigenesis, and chemoresistance are also noteworthy. The multiple roles of miR-30d-5p in human
cancer suggest that it has broad feasibility as a
biomarker and therapeutic target. This review describes the connection between miR-30d-5p and the clinical indications of
tumors, and summarizes the mechanisms by which miR-30d-5p mediates
cancer progression.