Abstract | IMPORTANCE: Autoimmune gastritis is an alternative cause of gastric carcinogenesis. This cause may be gaining importance with declining prevalence of chronic Helicobacter pylori infection. OBJECTIVE: DESIGN, SETTING, AND PARTICIPANTS: This cohort study used nested GC case-control analyses within separate Finnish cohorts of women of reproductive age (Finnish Maternity Cohort [FMC]; born 1938-1989) and older men ( Alpha-Tocopherol, Beta-Carotene Cancer Prevention [ATBC] Study; born 1916-1939). There were 529 and 457 matched pairs from the FMC and ATBC Study, respectively, with mean participant ages of 30.5 and 57.5 years and medians of 17 and 11 years from baseline to cancer diagnosis. Data analyses were performed between August 2019 and November 2020. EXPOSURES: MAIN OUTCOMES AND MEASURES: RESULTS: Of the 529 control participants in the FMC and 457 control participants in the ATBC Study, 53 (10%) women and 35 (7.7%) men were APCA seropositive, respectively, whereas 146 (28%) women and 329 (72%) men were H pylori seropositive. In the FMC, APCA seropositivity was statistically significantly associated with GC risk among H pylori-seronegative women (OR, 5.52; 95% CI, 3.16-9.64) but not H pylori-seropositive women (OR, 1.29; 95% CI, 0.64-2.60; P for interaction = .002). The APCA association with H pylori seronegativity was strongest for tumors in the fundus and corpus (OR, 24.84; 95% CI, 8.49-72.72). In the ATBC Study, APCA seropositivity was not associated with GC among either H pylori-seronegative men (OR, 0.99; 95% CI, 0.32-3.04) or H pylori-seropositive men (OR, 1.06; 95% CI, 0.60-1.88). In both cohorts, anti- intrinsic factor antibody seroprevalence was less than 2% among cases as well as controls and not statistically associated with GC risk. CONCLUSIONS AND RELEVANCE: Results of this cohort study demonstrate that autoantibody positivity may reflect subclinical autoimmune gastritis in younger women. The findings among young females and corpus subsite align with increasing cancer incidence trends for these groups. Stronger autoimmune associations in H pylori-seronegative individuals support a model of autoimmune gastritis replacing H pylori as the driving factor.
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Authors | Minkyo Song, M Constanza Camargo, Hormuzd A Katki, Stephanie J Weinstein, Satu Männistö, Demetrius Albanes, Heljä-Marja Surcel, Charles S Rabkin |
Journal | JAMA oncology
(JAMA Oncol)
Vol. 8
Issue 2
Pg. 268-274
(Feb 01 2022)
ISSN: 2374-2445 [Electronic] United States |
PMID | 34913949
(Publication Type: Journal Article, Research Support, N.I.H., Intramural)
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Chemical References |
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Topics |
- Adult
- Aged
- Autoantibodies
- Case-Control Studies
- Cohort Studies
- Female
- Helicobacter Infections
(complications, epidemiology, pathology)
- Helicobacter pylori
- Humans
- Male
- Middle Aged
- Pregnancy
- Seroepidemiologic Studies
- Stomach Neoplasms
(epidemiology)
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