Comparison of Serum Triiodothyronine with Biomarkers for Alzheimer's Disease Continuum in Euthyroid Subjects.

Abstract

BACKGROUND:

Accumulating studies have implicated thyroid dysfunction in the pathogenesis of Alzheimer's disease (AD).

OBJECTIVE:

This study aimed to explore the association between thyroid hormone (TH) levels and cerebrospinal fluid (CSF) biomarkers for AD continuum among euthyroid subjects.

METHODS:

In all, 93 clinically euthyroid subjects with a cognitive decline were included in this prospective cross-sectional study and were divided into groups with abnormal AD biomarkers (belonging to the "Alzheimer's continuum"; A+ patients) and those with "normal AD biomarkers" or "non-AD pathological changes" (A-patients), according to the ATN research framework classification for AD. A partial correlation analysis of serum thyroid-stimulating hormone (TSH) or TH levels with CSF biomarkers was conducted. The predictor for A+ patients was analyzed via binary logistic regressions. Finally, the diagnostic significance of individual biochemical predictors for A+ patients was estimated via receiver operating characteristic curve analysis.

RESULTS:

Serum total triiodothyronine (TT3) and free triiodothyronine (FT3) levels were found to affect the levels of CSF amyloid-β (Aβ)42 and the ratios of Aβ42/40. Further, FT3 was found to be a significant predictor for A+ via binary logistic regression modeling. Moreover, FT3 showed a high diagnostic value for A+ in euthyroid subjects.

CONCLUSION:

Even in a clinical euthyroid state, low serum FT3 and TT3 levels appear to be differentially associated with AD-specific CSF changes. These data indicate that serum FT3 is a strong candidate for differential diagnosis between AD continuum and non-AD dementia, which benefits the early diagnosis and effective management of preclinical and clinical AD patients.

• Authors: Feifei Ge, Lin Dong, Donglin Zhu, Xingjian Lin, Jingping Shi, Ming Xiao
• Journal: Journal of Alzheimer's disease : JAD (J Alzheimers Dis) Vol. 85 Issue 2 Pg. 605-614 ( 2022) ISSN: 1875-8908 [Electronic] Netherlands
• PMID: 34864671 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers
• Triiodothyronine
• Thyrotropin

Topics

• Aged
• Alzheimer Disease (metabolism, physiopathology)
• Biomarkers (blood, cerebrospinal fluid)
• Cognitive Dysfunction (metabolism)
• Cross-Sectional Studies
• Female
• Humans
• Logistic Models
• Male
• Middle Aged
• Neuropsychological Tests
• Prospective Studies
• ROC Curve
• Thyroid Function Tests
• Thyrotropin (blood, cerebrospinal fluid, metabolism)
• Triiodothyronine (blood, cerebrospinal fluid)