Abstract | BACKGROUND: AIM: METHODS: We reviewed a large, retrospective, cohort that utilized electronic health record data collected by the TriNetX Research Network, a global federated database that provides healthcare data for analysis. We performed multiple comparisons: men with ED against men without ED; men with ED treated with phosphodiesterase-5 inhibitors against untreated ED patients, and of men with ED who received penile prosthesis against those who did not. We assessed major depressive disorder (ICD-10-CM F32-F33) as a primary outcome and used propensity score matching to control for ethnicity, race, type 2 diabetes mellitus (E11), essential hypertension (I10), acute myocardial infarction (I21), chronic ischemic heart disease (I25), cerebral infarction (I63), overweight and obesity (E66), personal history of nicotine (Z87.891), hypogonadism (E29.1), and alcohol related disorders (F10). OUTCOMES: RESULTS: ED was associated with major depressive disorder both before and after (OR 2.00, 95% CI 1.94-2.06) controlling for confounding variables through propensity score matching. Men who received ED therapies had lower rates of depression compared to those who did not, whether they were treated with phosphodiesterase-5 inhibitor (0.80, 0.77-0.83) or penile prosthesis (0.73, 0.60-0.89). STRENGTHS AND LIMITATIONS: Strengths include a large sample size and robust statistical techniques. Limitations include lack of detailed information regarding clinical severity and socioeconomic factors. CLINICAL IMPLICATIONS: CONCLUSIONS:
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Authors | Sirpi Nackeeran, Amoghavarsha Havanur, Jesse Ory, Stanley Althof, Ranjith Ramasamy |
Journal | The journal of sexual medicine
(J Sex Med)
Vol. 18
Issue 12
Pg. 2005-2011
(12 2021)
ISSN: 1743-6109 [Electronic] Netherlands |
PMID | 34857255
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2021 International Society for Sexual Medicine. Published by Elsevier Inc. All rights reserved. |
Topics |
- Depressive Disorder, Major
(complications, epidemiology)
- Diabetes Mellitus, Type 2
(complications)
- Erectile Dysfunction
(drug therapy, epidemiology, etiology)
- Humans
- Male
- Retrospective Studies
- Risk Factors
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