Fructooligosaccharide ameliorates high-fat induced intrauterine inflammation and improves lipid profile in the hamster offspring.

Abstract

Maternal high-fat diet (HFD) often results in intrauterine and feto-placental inflammation, and increases the risks of fetal programming of metabolic diseases. Intake of prebiotic is reported beneficial. However, its effects on HFD during pregnancy and lactation is not known. We evaluated the maternal intake of fructooligosaccharide (FOS) and its impact on placental inflammation, offspring's adiposity, glucose, and lipid metabolism in their later life. Female Golden Syrian hamsters were fed with a control diet (CD, 26.4 % energy from fat) or HFD (60.7% energy from fat) in the presence or absence of FOS from preconception until lactation. All pups were switched over to CD after lactation and continued until the end. Placental inflammation was upregulated in HFD-fed dam, as measured by a high concentration of hsCRP in the serum and amniotic fluid. Neutrophil infiltration was significantly increased in the decidua through the chorionic layer of the placenta. The expression of pro-inflammatory cytokines such as COX2, NFκβ, IL-8, TGFβ mRNA was increased in the chorioamniotic membrane (P <.05). The HFD/CD hamsters had more adiposity, higher triglyceride, and low HDL at 12 months of age compared to CD/CD (P <.05). However, HFD+FOS/CD-fed hamsters prevented adverse effects such as placental inflammation, neutrophil infiltration, glucose, and lipid profiles in the offspring (P <.05). Anti-inflammatory and lipid-lowering effects of FOS may reduce placental inflammation by lowering neutrophil infiltration and decreasing the production of pro-inflammatory cytokines. Intake of FOS during pregnancy may be beneficial in maintaining lipid metabolism and preventing excess adiposity for mother and their offspring.

• Authors: Shujauddin Mohammed, Syed Shah Yousuf Qadri, Irfan Ahmad Mir, Narendra Babu Kondapalli, Sanjay Basak, Hemalatha Rajkumar
• Journal: The Journal of nutritional biochemistry (J Nutr Biochem) Vol. 101 Pg. 108925 (03 2022) ISSN: 1873-4847 [Electronic] United States
• PMID: 34843933 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2021. Published by Elsevier Inc.

Chemical References

• Blood Glucose
• Cytokines
• Lipids
• Lipoproteins, HDL
• Oligosaccharides
• Prebiotics
• Triglycerides
• fructooligosaccharide

Topics

• Adiposity
• Animals
• Blood Glucose (analysis)
• Body Weight
• Chorioallantoic Membrane (immunology)
• Cytokines (metabolism)
• Diet, High-Fat (adverse effects)
• Female
• Inflammation (prevention & control)
• Lipid Metabolism
• Lipids (blood)
• Lipoproteins, HDL (blood)
• Maternal Nutritional Physiological Phenomena
• Mesocricetus
• Neutrophil Infiltration
• Oligosaccharides
• Placenta (immunology)
• Prebiotics
• Pregnancy
• Triglycerides (blood)