Abstract | PURPOSE: Monocyte subsets, including classical, intermediate and non-classical monocytes, are involved in the pathogenesis of inflammatory or autoimmune diseases. The pathogenic role of monocytes in the peripheral blood mononuclear cells (PBMCs) of patients with rosacea remains unclear. This study aimed to assess frequencies of monocyte subsets in PBMCs from rosacea patients before and after clinical treatment. PATIENTS AND METHODS: RESULTS: The frequency of classical monocytes, but not intermediate or non-classical monocytes, was higher in rosacea as compared with HC, which decreased after treatment. Frequencies of monocyte subsets showed no gender difference, while increased with age in patients but not in HC. Frequencies of classical monocytes in patients with erythematotelangiectatic rosacea (ETR) and ETR- papulopustular rosacea (PPR) overlap were significantly higher than HC or patients with only PPR or phymatous rosacea (PhR). There was a significant higher expression of CCR2 in classical monocytes, with higher plasma levels of CCL2, HMGB-1, IL-1β and TNF-α in patients than in HC, which all significantly decreased after treatment. CONCLUSION: Our data indicated a possible association between abnormal classical monocytes frequencies and rosacea.
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Authors | Cuie Gao, Lan Ge, Dewei Chen, Mengjie Zhang, Li Zhao, Wenying Liu, Shuguang Chen, Juan Wang, Cunjian Zhou, Xingwang Zhao, Shifei Li, Zhiqiang Song, Jian Li |
Journal | Clinical, cosmetic and investigational dermatology
(Clin Cosmet Investig Dermatol)
Vol. 14
Pg. 1629-1636
( 2021)
ISSN: 1178-7015 [Print] New Zealand |
PMID | 34803388
(Publication Type: Journal Article)
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Copyright | © 2021 Gao et al. |