Oral cavity response to air pollutant exposure and association with pulmonary inflammation and symptoms in asthmatic children.

Abstract

Exposure to fine particulate matter (PM2.5) and ozone (O3) may lead to inflammation and oxidative damage in the oral cavity, which is hypothesized to contribute to the worsening of airway inflammation and asthma symptoms. In this panel study of 43 asthmatic children aged 5-13 years old, each child had 4 clinic visits with a 2-week interval between two consecutive visits. At each visit, saliva samples were collected and subsequently analyzed for interleukin 6 (IL-6) and eosinophil cationic protein (ECP) as biomarkers of inflammation and malondialdehyde (MDA) as a biomarker of oxidative stress in the oral cavity. At each visit, children were measured for fractional exhaled nitric oxide (FeNO) as a marker of pulmonary inflammation. Asthma symptoms of these children were measured using the Childhood Asthma Control Test (C-ACT). We found that an interquartile range (IQR) increase in 24-h average personal exposure to PM2.5 measured 1 and 2 days prior was associated with increased salivary IL-6 concentration by 3.0% (95%CI: 0.2%-6.0%) and 4.2% (0.7%-8.0%), respectively. However, we did not find a clear association between personal O3 exposure and any of the salivary biomarkers, except for a negative association between salivary MDA and O3 exposure measured 1 day prior. An IQR increase in salivary IL-6 concentration was associated with significantly increased FeNO by 28.8% (4.3%-53.4%). In addition, we found that increasing salivary IL-6 concentrations were associated with decreased individual and total C-ACT scores, indicating the worsening of asthma symptoms. We estimated that 13.2%-22.2% of the associations of PM2.5 exposure measured 1 day prior with FeNO and C-ACT scores were mediated by salivary IL-6. These findings suggest that the induction of inflammation in the oral cavity may have played a role in linking air pollution exposure with the worsening of airway inflammation and asthma symptoms.

• Authors: Linchen He, Christina Norris, Xiaoxing Cui, Zhen Li, Karoline K Barkjohn, Yanbo Teng, Lin Fang, Lili Lin, Qian Wang, Xiaojian Zhou, Jianguo Hong, Feng Li, Yinping Zhang, James J Schauer, Marilyn Black, Michael H Bergin, Junfeng Jim Zhang
• Journal: Environmental research (Environ Res) Vol. 206 Pg. 112275 (04 15 2022) ISSN: 1096-0953 [Electronic] Netherlands
• PMID: 34710437 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2021 Elsevier Inc. All rights reserved.

Chemical References

• Air Pollutants
• Particulate Matter

Topics

• Adolescent
• Air Pollutants (analysis, toxicity)
• Air Pollution (analysis)
• Asthma (chemically induced, metabolism)
• Child
• Child, Preschool
• Environmental Exposure (adverse effects)
• Humans
• Inflammation (chemically induced)
• Mouth (chemistry, metabolism)
• Particulate Matter (analysis, toxicity)
• Pneumonia