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Novel β-mannanase/GLP-1 fusion peptide high effectively ameliorates obesity in a mouse model by modifying balance of gut microbiota.

Abstract
We constructed a novel β-mannanase/GLP-1 fusion peptide, termed MGLP_1, and evaluated its ability to ameliorate obesity in a high-fat/high-sugar diet (HFSD)-induced mouse model. Eight-wk MGLP_1 treatment notably reduced obesity, as reflected by significant changes of body weight, serum triglyceride level, fatty liver and adipose tissue distribution. Amelioration of HFSD-induced gut dysbiosis by MGLP_1 was evidenced by reduced abundance ratio of bacterial phyla Firmicutes to Bacteroidetes, enhanced abundance of beneficial probiotic genera (Bifidobacterium, Lachnospiraceae, Ileibacterium), and reduced abundance of harmful genera (Clostridium, Romboutsia). Mechanisms of weight loss were investigated by comparing effects of treatment with MGLP_1 vs. prebiotics manno-oligosaccharides (MOS). MGLP_1 ameliorated gut microbiota imbalance by enhancing carbohydrate catabolism, whereas MOS promoted glycan synthesis and metabolism. Our findings, taken together, indicate that MGLP_1 fusion peptide has strong potential for amelioration of obesity by modifying relationships between gut microbiota and lipid and glucose metabolism.
AuthorsYan Wang, Nuraliya Ablimit, Yunpeng Zhang, Jifu Li, Xinrui Wang, Junquan Liu, Ting Miao, Lei Wu, Hui Wang, Zengli Wang, Huiqiang Lou, Wei Jiang
JournalInternational journal of biological macromolecules (Int J Biol Macromol) Vol. 191 Pg. 753-763 (Nov 30 2021) ISSN: 1879-0003 [Electronic] Netherlands
PMID34592220 (Publication Type: Journal Article)
CopyrightCopyright © 2021 Elsevier B.V. All rights reserved.
Chemical References
  • Anti-Obesity Agents
  • Recombinant Proteins
  • Glucagon-Like Peptide 1
  • beta-Mannosidase
  • Glucose
Topics
  • Animals
  • Anti-Obesity Agents (chemistry, therapeutic use)
  • Gastrointestinal Microbiome
  • Glucagon-Like Peptide 1 (genetics, metabolism)
  • Glucose (metabolism)
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Obesity (drug therapy, microbiology)
  • Recombinant Proteins (chemistry, genetics, therapeutic use)
  • beta-Mannosidase (genetics, metabolism)

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