Apolipoprotein B is a novel marker for early tau pathology in Alzheimer's disease.

Abstract

INTRODUCTION:

We examine the role of brain apolipoprotein B (apoB) as a putative marker of early tau pathology and cognitive decline.

METHODS:

Cerebrospinal fluid (CSF) samples from cognitively normal and Alzheimer's disease (AD) participants were collected to measure protein levels of apoB and AD biomarkers amyloid beta (Aβ), t-tau and p-tau, as well as synaptic markers GAP43, SYNAPTOTAGMIN-1, synaptosome associated protein 25 (SNAP-25), and NEUROGRANIN. CSF apoB levels were contrasted with positron emission tomography (PET) scan measures of Aβ (18F-NAV4694) and Tau (flortaucipir) along with cognitive assessment alterations over 6 to 8 years.

RESULTS:

CSF apoB levels were elevated in AD participants and correlated with t-tau, p-tau, and the four synaptic markers in pre-symptomatic individuals. In the latter, CSF apoB levels correlated with PET flortaucipir-binding in entorhinal, parahippocampal, and fusiform regions. Baseline CSF apoB levels were associated with longitudinal visuospatial cognitive decline.

DISCUSSION:

CSF apoB markedly associates with early tau dysregulation in asymptomatic subjects and identifies at-risk individuals predisposed to develop visuospatial cognitive decline over time.

• Authors: Cynthia Picard, Nathalie Nilsson, Anne Labonté, Daniel Auld, Pedro Rosa-Neto, Alzheimer's Disease Neuroimaging Initiative, Nicholas J Ashton, Henrik Zetterberg, Kaj Blennow, John C B Breitner, Sylvia Villeneuve, Judes Poirier, PREVENT-AD research group
• Journal: Alzheimer's & dementia : the journal of the Alzheimer's Association (Alzheimers Dement) Vol. 18 Issue 5 Pg. 875-887 (05 2022) ISSN: 1552-5279 [Electronic] United States
• PMID: 34590423 (Publication Type: Journal Article)
• Copyright: © 2021 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.

Chemical References

• APOB protein, human
• Amyloid beta-Peptides
• Apolipoprotein B-100
• Apolipoproteins
• Apolipoproteins B
• Biomarkers
• tau Proteins

Topics

• Alzheimer Disease (metabolism)
• Amyloid beta-Peptides (metabolism)
• Apolipoprotein B-100
• Apolipoproteins
• Apolipoproteins B
• Biomarkers (cerebrospinal fluid)
• Cognitive Dysfunction (metabolism)
• Humans
• Positron-Emission Tomography (methods)
• tau Proteins (cerebrospinal fluid)