Abstract | BACKGROUND: CASE PRESENTATION: We herein report a case of refractory and relapsed multiple myeloma that developed bilateral MPE due to disease progression caused by intolerance to various chemotherapy regimens. Cytomorphology and flow cytometry were adopted for diagnosis confirmation. Chemotherapy containing immunomodulators combined with thoracic catheterization drainage was applied to the patient, showing a certain therapeutic effect. During the course of disease, the change of cytokine profile in pleural effusion was monitored by cytometric bead array (CBA) technology, revealing that cytokines related to tumor load such as interleukin 6 (IL-6) and interleukin 10 (IL-10) in pleural effusion decreased with the improvement of disease, while other cytokines such as interleukin 2 (IL-2), interleukin 4 (IL-4), interleukin 17A (IL-17A), tumor necrosis factor α (TNF-α), interferon γ (IFN-γ), granzyme A, granzyme B, perforin and granulysin increased with the improvement of disease. CONCLUSION: There is a prospect that cytokine level in pleural effusion may indicate treatment response of MPE, and in light of this case, immunomodulators may be utilized in treating patients suffering MPE. Due to limitations of our single case, we urge more groups to evaluate the potential role of cytokine profile in MPE.
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Authors | Junhui Xu, Liang Gao, Miao Yan, Bingjie Wang, Zhengyang Song, Huihui Liu, Kunyan Sun, Lin Nong, Mangju Wang, Xinan Cen |
Journal | OncoTargets and therapy
(Onco Targets Ther)
Vol. 14
Pg. 4545-4550
( 2021)
ISSN: 1178-6930 [Print] New Zealand |
PMID | 34466000
(Publication Type: Case Reports)
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Copyright | © 2021 Xu et al. |