Roles of MicroRNAs in Peripheral Artery In-Stent Restenosis after Endovascular Treatment.

Abstract

Endovascular repair including percutaneous transluminal angioplasty (PTA) and stent implantation has become the standard approach for the treatment of peripheral arterial disease; however, restenosis is still the main limited complication for the long-term success of the endovascular repair. Endothelial denudation and regeneration, inflammatory response, and neointimal hyperplasia are major pathological processes occurring during in-stent restenosis (ISR). MicroRNAs exhibit great potential in regulating several vascular biological events in different cell types and have been identified as novel therapeutic targets as well as biomarkers for ISR prevention. This review summarized recent experimental and clinical studies on the role of miRNAs in ISR modification, with the aim of unraveling the underlying mechanism and potential therapeutic strategy of ISR.

• Authors: Mo Wang, Weichang Zhang, Lei Zhang, Lunchang Wang, Jiehua Li, Chang Shu, Xin Li
• Journal: BioMed research international (Biomed Res Int) Vol. 2021 Pg. 9935671 ( 2021) ISSN: 2314-6141 [Electronic] United States
• PMID: 34368362 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2021 Mo Wang et al.

Chemical References

• Biomarkers
• MicroRNAs

Topics

• Animals
• Arteries (metabolism, physiopathology)
• Biomarkers (metabolism)
• Coronary Restenosis (blood, genetics, therapy)
• Endovascular Procedures
• Humans
• MicroRNAs (blood, genetics, metabolism)
• Stents