Alzheimer's disease (AD), one of the progressive
neurodegenerative disorders, is characterized by clinical features such as
memory loss, acquired skill loss,
apraxia, and interpersonal and
social communication disorders. The AD hallmarks at the neuropathological level include intracellular neurofibrillary tangles constituted by the hyperphosphorylated
tau protein as well as the senile extracellular plaques dominated by the
amyloid-β (Aβ) deposits. At present, AD treatment that mainly targeted towards improving symptoms and effective drugs to delay or stop
disease progression is lacking.
Vaccines and antibody-based
therapies are a type of natural, synthetic, and gene recombinant
biological product that treat or prevent
disease progression by stimulating specific or non-specific immune responses. Compared with traditional targeted drugs,
vaccines and antibodybased
therapies have better safety and effectiveness and can even maintain the expression and stability of Aβ and
Tau proteins in patients for a long time. Logically,
vaccines and antibody-based
therapies are somewhat different from traditional drugs because these drugs can achieve the
therapeutic effect of AD by activating immune cells and regulating the immune system of patients themselves, thereby clearing disease-related
proteins and long-term survival. Complete cure is also observed in some patients after receiving the
immunotherapy. Currently available
vaccines and antibody-based
therapies mainly target Aβ and phosphorylated
tau proteins. There are 44
vaccines and antibodybased
therapies for AD, among which nine drugs are discontinued, three drugs are inactive, eleven drugs are in clinical phase 1, twelve drugs are in clinical phase 2, and seven drugs are in clinical phase 3. Currently, no
vaccines and antibody-based
therapies have been approved for AD treatment. In this paper, we review and analyse the research progress of
vaccines and antibody-based
therapies that are used to treat AD.