Non-invasive diagnosis and follow-up of chronic infection with Hepatitis C Virus.

Abstract

Hepatitis C virus (HCV) infection is a major cause of chronic liver disease. Clinical care for patients with HCV-related liver disease has advanced considerably with developments in screening, diagnostic procedures to evaluate liver fibrosis and improvements in therapy with pangenotypic direct antivirals and prevention. These AFEF guidelines on the non-invasive diagnosis and follow up of chronic infection with HCV describe the optimal management of HCV positive patients with non-invasive methods in screening, in assessing viral disease and liver fibrosis and the follow-up of these patients according to the value of FibroScan®, Fibrotest® or Fibrometer®. Hepatocellular carcinoma screening must continue in patients with liver stiffness by FibroScan® ≥10 kPa or Fibrotest® >0.58 or Fibrometer® >0.78 prior to treatment initiation. After reaching sustained virologic response, patients with a measurement of liver stiffness by FibroScan®<10 kPa or Fibrotest®≤0.58 or Fibrometer®≤0.78 before treatment initiation and without liver comorbidity (alcohol consumption, metabolic syndrome, HBV co-infection etc.) no longer require specific monitoring. The role of liver biopsy is discussed in some rare situations.

• Authors: Albert Tran, Sarah Shili-Masmoudi, Lucile Moga, Stéphane Chevaliez, Alain Luciani, Isaac Ruiz, Nathalie Ganne-Carrié, Christophe Bureau, Marc Bourlière, Victor de Lédinghen
• Journal: Clinics and research in hepatology and gastroenterology (Clin Res Hepatol Gastroenterol) Vol. 46 Issue 1 Pg. 101771 (01 2022) ISSN: 2210-741X [Electronic] France
• PMID: 34332129 (Publication Type: Journal Article, Practice Guideline)
• Copyright: Copyright © 2021. Published by Elsevier Masson SAS.

Topics

• Elasticity Imaging Techniques (methods)
• Follow-Up Studies
• Hepacivirus
• Hepatitis C (complications)
• Hepatitis C, Chronic (complications, diagnosis, drug therapy)
• Humans
• Liver (pathology)
• Liver Cirrhosis (diagnosis, etiology, pathology)
• Liver Diseases (complications)
• Persistent Infection