A nomogram to predict microvascular invasion in early hepatocellular carcinoma.

Abstract

AIM:

To construct an integrated nomogram combining protein induced by vitamin K antagonist-II (PIVKA-II), alpha fetoprotein (AFP) and other clinical factors to detect microvascular invasion (MVI) in early hepatocellular carcinoma (HCC) patients with single nodule.

METHODS:

One hundred and eleven early HCC patients were enrolled in the present study and 43 early HCC patients were diagnosed with MVI. Serum levels of PIVKA-II, AFP and other laboratory indicators were detected. Chi-squared test, t-test and logistic regression were employed in statistic analysis. A nomogram combining independent predictors was constructed and internal validated.

RESULTS:

In early HCC patients with MVI, PIVKA-II serum level was significantly higher than those without MVI (385.97 mAU/ml vs 67.08 mAU/ml; P < 0.01), as well as AFP serum level (81.6 ng/mL vs 9.15 ng/mL P = 0.001). PIVAK-II, AFP serum levels and tumor size were independent risk factors for MVI in early HCC, which was employed to develop a logistic regression model. The area under the ROC curve (AUROC) of the model was 0.74 (95%CI 0.65 - 0.84). A nomogram combining PIVKA-II, AFP and tumor size was constructed and calibration curves showed that the model was accurate in predicting the risk of MVI in early HCC patients.

CONCLUSION:

The present study indicates that a preoperative nomogram combining PIVKA-II, AFP and tumor size could estimate the preoperative probability of MVI in early HCC patients, which may help clinicians in choosing treatment options and prognosis evaluation.

• Authors: Hongguang Li, Tao Li, Jinhua Hu, Jun Liu
• Journal: Journal of cancer research and therapeutics (J Cancer Res Ther) Vol. 17 Issue 3 Pg. 652-657 (Jul 2021) ISSN: 1998-4138 [Electronic] India
• PMID: 34269295 (Publication Type: Journal Article)

Chemical References

• AFP protein, human
• Biomarkers
• Biomarkers, Tumor
• Protein Precursors
• alpha-Fetoproteins
• acarboxyprothrombin
• Prothrombin

Topics

• Aged
• Biomarkers (blood)
• Biomarkers, Tumor (blood)
• Carcinoma, Hepatocellular (blood, diagnosis, pathology, surgery)
• Clinical Decision-Making (methods)
• Hepatectomy
• Humans
• Liver (blood supply, pathology)
• Liver Neoplasms (blood, diagnosis, pathology, surgery)
• Male
• Microvessels (pathology)
• Middle Aged
• Neoplasm Invasiveness
• Neoplasm Staging
• Nomograms
• Preoperative Period
• Protein Precursors (blood)
• Prothrombin
• ROC Curve
• Retrospective Studies
• Tumor Burden
• alpha-Fetoproteins (analysis)