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Dysembryoplastic neuroepithelial tumors: A single-institutional series with special reference to glutamine synthetase expression.

Abstract
Dysembryoplastic neuroepithelial tumors (DNT) is a benign (World Health Organisation, WHO, grade I) glioneuronal tumor and it represent one of the most frequent neoplasm in patient affected by seizures. The epileptic neuronal activity can be determined by abnormal synchronization, excessive glutamate excitation and\or inadequate GABA inhibition. Increasing evidence suggests that the astrocytes might be involved in this process even if neurons play a relevant role. In particular astrocytes promote the clearance of glutamate, a potent excitatory neurotransmitter of the central nervous system. Indeed, elevated concentrations of extracellular glutamate may determine iper-excitability and seizures as well as other neurological disorders. So, astrocytes, converting glutamate into glutamine via the enzyme glutamine synthetase (GS), could play a protective anti-seizures role. In the present study, we analyzed the immunohistochemical expression of GS in 20 DNTs specimens documenting a constant immunoistochemical expression of GS in astrocytes of the lesional tissue and of the cerebral cortex.
AuthorsChiara Caporalini, Mirko Scagnet, Selene Moscardi, Gioia Di Stefano, Gianna Baroni, Flavio Giordano, Federico Mussa, Carmen Barba, Iacopo Sardi, Lorenzo Genitori, Anna Maria Buccoliero
JournalAnnals of diagnostic pathology (Ann Diagn Pathol) Vol. 54 Pg. 151774 (Oct 2021) ISSN: 1532-8198 [Electronic] United States
PMID34182416 (Publication Type: Journal Article)
CopyrightCopyright © 2021 Elsevier Inc. All rights reserved.
Chemical References
  • Glutamate-Ammonia Ligase
Topics
  • Adolescent
  • Astrocytes (metabolism, pathology)
  • Brain Neoplasms (metabolism, pathology)
  • Child
  • Child, Preschool
  • Female
  • Glioma (metabolism, pathology)
  • Glutamate-Ammonia Ligase (metabolism)
  • Humans
  • Immunohistochemistry (methods)
  • Male
  • Neoplasms, Neuroepithelial (metabolism, pathology)
  • Neurons (pathology)
  • Young Adult

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