High Expression of Cyclin D1 is an Independent Marker for Favorable Prognosis in Middle Eastern Breast Cancer.

Abstract

PURPOSE:

The cyclin D1 protein regulates cell cycle progression which is mediated by its interactions with cyclin-dependent kinases. Over-expression of cyclin D1 has been observed in several human cancers. This study was conducted to evaluate cyclin D1 expression in a large cohort of Middle Eastern breast cancers and determine its prognostic significance.

PATIENTS AND METHODS:

Cyclin D1 expression was assessed immunohistochemically and its association with clinico-pathological parameters was analyzed in 1003 breast cancer patients.

RESULTS:

Cyclin D1 was over-expressed in 59.4% (596/1003) of cases and significantly associated with a subset of breast cancers having favorable prognostic features, such as low grade (p < 0.0001), low stage (p = 0.0276), estrogen receptor (p < 0.0001) and progesterone receptor positive (p < 0.0001) tumors. An inverse association was found with triple negative breast cancers (p < 0.0001). More importantly, cyclin D1 expression was an independent predictor of favorable overall survival in our cohort (hazard ratio = 0.70; 95% confidence interval = 0.50-0.98; p = 0.0395). Also, tumors that highly expressed cyclin D1 had a longer recurrence-free survival. However, this significant association was seen only in univariate analysis. We also found cyclin D1 to be associated with phospho-Rb in luminal subtype of breast cancer and co-expression of both these markers was an independent predictor of luminal A breast cancer.

CONCLUSION:

Our results reinforced the role of cyclin D1 in breast cancer pathology and revealed its expression as a valuable independent prognostic indicator for breast cancer from Middle Eastern ethnicity.

• Authors: Abdul K Siraj, Sandeep Kumar Parvathareddy, Padmanaban Annaiyappanaidu, Saeeda O Ahmed, Nabil Siraj, Asma Tulbah, Fouad Al-Dayel, Dahish Ajarim, Khawla S Al-Kuraya
• Journal: OncoTargets and therapy (Onco Targets Ther) Vol. 14 Pg. 3309-3318 ( 2021) ISSN: 1178-6930 [Print] New Zealand
• PMID: 34040395 (Publication Type: Journal Article)
• Copyright: © 2021 Siraj et al.