CircRNAs have been reported to play essential roles in regulating immunity and
inflammation, which may be an important regulatory factor in the development of
vitiligo. However, the expression profile of
circRNAs and their potential biological functions in
vitiligo have not been reported so far. In our study we found there are 64 dysregulated
circRNAs and 14 dysregulated
miRNAs in the patients with
vitiligo. Through the correlation analysis, we obtained 12 dysregulated
circRNAs and 5 dysregulated
miRNAs, forming 48 relationships in the
circRNA-
miRNA-
mRNA regulatory network. Gene Ontology analysis indicated dysregulated
circRNAs in
vitiligo is closely related to the disorder of the metabolic pathway. The KEGG pathway of dysregulation of
circRNAs mainly enriched in the biological processes such as
ubiquitin mediated proteolysis, endocytosis and RNA degradation, and in Jak-STAT signaling pathway. Therefore, we found the
circRNA-
miRNA-
mRNA regulatory network are involved in the regulation of numerous melanocyte functions, and these dysregulated
circRNAs may closely related to the melanocyte metabolism. Our study provides a theoretical basis for studying the
vitiligo pathogenesis from the perspective of
circRNA-
miRNA-
mRNA network.