Abstract | INTRODUCTION: METHODS AND ANALYSIS: We propose a longitudinal cohort study in which we will link data from the CanBEST and BSC study with routinely collected data from provincial health administrative databases. Our outcome is asthma incidence measured using a validated health administrative data algorithm. Primary exposure will be treatment with a combined therapy of high-dose corticosteroids and nebulised epinephrine for bronchiolitis. Covariates will include type of viral pathogen, disease severity, medication use, maternal, prenatal, postnatal and demographic factors and variables related to health service utilisation for acute lower respiratory tract infection. The risk associated with development of asthma in children treated with high-dose corticosteroid and epinephrine for bronchiolitis will be assessed using multivariable Cox proportional hazards regression models. Prediction models will be developed using multivariable logistic regression analysis and internally validated using a bootstrap approach. ETHICS AND DISSEMINATION: Our study has been approved by the ethics board of all four participating sites of the CanBEST and BSC study. Finding of the study will be disseminated to the academic community and relevant stakeholders through conferences and peer-reviewed publications. TRIAL REGISTRATION NUMBER: ISRCTN56745572; Post-results.
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Authors | Kawsari Abdullah, Deshayne B Fell, Dhenuka Radhakrishnan, Steven Hawken, David W Johnson, Piush Mandhane, Teresa To, Gary Joubert, Amy C Plint, for Pediatric Emergency Research Canada |
Journal | BMJ open
(BMJ Open)
Vol. 11
Issue 5
Pg. e048823
(05 03 2021)
ISSN: 2044-6055 [Electronic] England |
PMID | 33941638
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. |
Topics |
- Asthma
(drug therapy, epidemiology)
- Bronchiolitis
(drug therapy, epidemiology)
- Canada
- Child
- Child, Preschool
- Cohort Studies
- Emergency Service, Hospital
- Female
- Humans
- Infant
- Longitudinal Studies
- Pregnancy
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