Abstract | BACKGROUND: OBJECTIVES: This study tested whether a high sodium (HS) diet reduces orthostatic tachycardia (Δ heart rate) and upright heart rate compared with a low sodium (LS) diet in POTS patients, and secondarily its effect on plasma volume (PV) and plasma norepinephrine. METHODS: A total of 14 POTS patients and 13 healthy control subjects (HC), age 23 to 49 years, were enrolled in a crossover study with 6 days of LS (10 mEq sodium/day) or HS (300 mEq sodium/day) diet. Supine and standing heart rate, blood pressure, serum aldosterone, plasma renin activity, blood volume, and plasma norepinephrine and epinephrine were measured. RESULTS: In POTS, the HS diet reduced upright heart rate and Δ heart rate compared with the LS diet. Total blood volume and PV increased, and standing norepinephrine decreased with the HS compared with the LS diet. However, upright heart rate, Δ heart rate, and upright norepinephrine remained higher in POTS than in HC on the HS diet (median 117 beats/min [interquartile range: 98 to 121 beats/min], 46 beats/min [interquartile range: 32 to 55 beats/min], and 753 pg/ml [interquartile range: 498 to 919 pg/ml] in POTS vs. 85 beats/min [interquartile range: 77 to 95 beats/min], 19 beats/min [interquartile range: 11 to 32 beats/min], and 387 pg/ml [interquartile range: 312 to 433 pg/ml] in HC, respectively), despite no difference in the measured PV. CONCLUSIONS:
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Authors | Emily M Garland, Alfredo Gamboa, Victor C Nwazue, Jorge E Celedonio, Sachin Y Paranjape, Bonnie K Black, Luis E Okamoto, Cyndya A Shibao, Italo Biaggioni, David Robertson, André Diedrich, William D Dupont, Satish R Raj |
Journal | Journal of the American College of Cardiology
(J Am Coll Cardiol)
Vol. 77
Issue 17
Pg. 2174-2184
(05 04 2021)
ISSN: 1558-3597 [Electronic] United States |
PMID | 33926653
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural)
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Copyright | Copyright © 2021 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Biomarkers
- Sodium, Dietary
- Norepinephrine
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Topics |
- Adult
- Biomarkers
(blood)
- Blood Pressure
(physiology)
- Cross-Over Studies
- Female
- Heart Rate
(physiology)
- Humans
- Male
- Middle Aged
- Norepinephrine
(blood)
- Postural Orthostatic Tachycardia Syndrome
(blood, physiopathology, therapy)
- Posture
(physiology)
- Sodium, Dietary
(administration & dosage)
- Young Adult
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