Tachycardia (Tachyarrhythmias)

Abnormally rapid heartbeat, usually with a HEART RATE above 100 beats per minute for adults. Tachycardia accompanied by disturbance in the cardiac depolarization (cardiac arrhythmia) is called tachyarrhythmia.

Also Known As:

Networked: 11609 relevant articles (749 outcomes, 888 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Hypertension (High Blood Pressure)
2.	Atrial Fibrillation
3.	Tachycardia (Tachyarrhythmias)
4.	Ventricular Tachycardia
5.	Cardiac Arrhythmias (Arrythmia)

Experts

1.	Nattel, Stanley: 28 articles (08/2015 - 05/2002)
2.	Moss, Arthur J: 26 articles (12/2015 - 01/2004)
3.	Zareba, Wojciech: 24 articles (12/2015 - 11/2004)
4.	McNitt, Scott: 20 articles (10/2015 - 12/2004)
5.	Aizawa, Yoshifusa: 18 articles (01/2012 - 08/2002)
6.	Eckardt, Lars: 17 articles (01/2016 - 01/2002)
7.	Boriani, Giuseppe: 17 articles (06/2015 - 06/2002)
8.	Belardinelli, Luiz: 15 articles (12/2015 - 09/2003)
9.	Chinushi, Masaomi: 15 articles (08/2010 - 08/2002)
10.	Goldenberg, Ilan: 14 articles (12/2015 - 09/2006)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Tachycardia:

1.	Amiodarone (Amiodarona)FDA LinkGeneric 04/01/2001 - "Antiarrhythmic agents with amiodarone-like electrophysiological actions, but with a more favorable pharmacokinetic profile than amiodarone would be extremely useful for the treatment of many tachyarrhythmias. " 12/01/1997 - "Amiodarone is highly effective in suppressing ventricular and supraventricular tachyarrhythmias. " 04/01/1996 - "Intravenous amiodarone is safe and effective in most young patients with critical tachyarrhythmia. " 12/01/1995 - "After several days of loading, oral amiodarone, a class III antiarrhythmic, is highly effective in controlling ventricular tachyarrhythmias; however, the delay in onset of activity is not acceptable in patients with immediately life-threatening arrhythmias. " 01/01/1992 - "In the present case, as in the others reported in the literature, the drug of choice seems to be Amiodarone which appears to be the most effective in preventing tachyarrhythmias caused by swallowing."
2.	Sotalol (Sotalol Hydrochloride)FDA LinkGeneric 09/01/1987 - "In preliminary studies sotalol appeared effective in most forms of supraventricular tachyarrhythmias with its effects being similar to those of other beta-blockers. " 07/01/1987 - "In contrast, sotalol was highly effective in preventing the induction of reentrant ventricular tachyarrhythmias. " 10/01/2011 - "High-dose sotalol is safe and effective in neonates and infants with refractory supraventricular tachyarrhythmias." 12/01/2001 - "Sotalol, being an effective and safe drug particularly in children, is a good therapeutic alternative for the preventive treatment of childhood tachyarrhythmias." 09/01/2011 - "Sotalol is more effective in the prevention of supraventricular tachyarrhythmia than placebo or beta-blockers. "
3.	Verapamil (Calan)FDA LinkGeneric 01/01/1986 - "Intravenous verapamil is highly effective in the termination of paroxysmal reciprocating atrioventricular tachycardia, whether associated with preexcitation or involving the atrioventricular node alone. " 03/01/1985 - "In AV nodal re-entrant tachycardia, verapamil was the most effective for termination. " 09/15/2005 - "The main results showed that treatment with verapamil was associated with a trend towards an higher percentage of atrial pacing in comparison with control (mean value+/-S.D.=63.2+/-29.9% vs. 57.3+/-30.6%, median value 53% vs. 49%, P value at Wilcoxon signed rank test=0.069), but without any significant reduction in atrial tachyarrhythmia burden (4.5+/-11.8 vs. 3.3+/-9.1%) or total hours spent in atrial tachyarrhythmia (65+/-161 vs. 48+/-131 h). " 02/01/2001 - "In electrophysiologic studies, intravenously administered verapamil was effective for the termination of tachycardia in all six patients who received this treatment and for the prevention of tachycardia in four of five patients. " 03/15/1989 - "A second IV administration of verapamil was effective in reversal of the atrial tachycardia, and a tapering dosage of verapamil, PO, was used to maintain normal sinus rhythm."
4.	Anti-Arrhythmia AgentsIBA 06/01/1987 - "It can be administered safely to patients with sustained ventricular tachyarrhythmias and is as effective as approved antiarrhythmic drugs when assessed by electropharmacologic testing." 09/01/1993 - "Many new antiarrhythmic drugs effective in supraventricular tachyarrhythmia are now available. " 07/01/2001 - "TWA may also be a useful marker for evaluating the efficacy of antiarrhythmic drugs for ventricular tachyarrhythmias." 01/01/1993 - "In principle, all antiarrhythmic drugs (classes 1-3) are useful in the treatment of ventricular tachyarrhythmias. " 01/01/2007 - "In 44 patients (3 women and 41 men, mean age 54 +/- 11 years) with malignant ventricular tachyarrhythmias (MVT) we assessed dependence of results of testing of antiarrhythmic drugs and efficacy of their long term use for prevention of recurrences of MVT on topography of derangement of local left ventricular (LV) contractility. "
5.	AdenosineFDA LinkGeneric 01/01/2015 - "Adenosine is an effective agent for termination of most re-entrant supraventricular arrhythmias involving the atrioventricular node and often also used as a diagnostic agent for wide QRS tachycardias. " 05/30/1999 - "It is emphasized that intravenous adenosine is highly effective in terminating sinus node, atrioventricular (AV) nodal and AV-reciprocating reentrant tachycardias. " 10/01/1999 - "However, for wide complex tachyarrhythmias, the diagnostic accuracy of the housestaff group significantly improved with the use of adenosine (pre = 54%, post = 70%, p < 0.01), while the attending physician group had no significant improvement (pre = 61%, post = 71%, p = NS). " 03/01/2001 - "The antiarrhythmic efficacy of adenosine during states of AV-nodal reentrant tachycardias is well known and clinically established. " 08/01/1998 - "Adenosine is an antiarrhythmic substance particularly effective in catecholamine-dependent tachycardias. "
6.	Flecainide (Tambocor)FDA LinkGeneric 01/01/1988 - "This experience demonstrates that flecainide is highly effective in refractory atrial tachyarrhythmias. " 11/01/1985 - "Flecainide acetate is a recently introduced, class 1 antiarrhythmic agent that is highly effective in the treatment of ventricular and atrioventricular/nodal reentrant tachycardias. " 04/01/1990 - "Two infants with chaotic atrial tachycardia diagnosed at birth and at 11 weeks of life, were treated successfully with oral flecainide. " 03/01/2013 - "Oral flecainide is effective in management of refractory tachycardia in infants." 02/01/1990 - "It is suggested that flecainide might be effective in the treatment of atrial tachyarrhythmias."
7.	Propafenone (Rythmol)FDA LinkGeneric 12/01/2012 - "In patients with non-inducible AVNRT, but without complete ventriculo-atrial block, propafenone was more effective in patients with shorter echo zone of tachycardia." 12/01/2012 - "In patients with non-inducible tachycardia, complete ventriculo-atrial block can be used as an electrophysiological predictor of the efficacy of propafenone oral therapy in the prevention of tachycardia. " 12/01/2012 - "Group A had significantly lower incidence of tachycardia than group B (95% vs 70.8%, P=0.038), and complete ventriculo-atrial block predicted the efficacy of propafenone oral therapy in the prevention of tachycardia (sensitivity 87.5%, specificity 52.8%, positive predictive value 95%, negative predictive value 29.2%). " 01/01/1995 - "Propafenone is a potent antiarrhythmic agent effective in either supraventricular or ventricular tachyarrhythmias. " 04/01/1990 - "Seven of the 13 children (53.8%) with ventricular ectopics, all three children with paroxysmal re-entry atrioventricular tachycardia, and two of the three children with paroxysmal atrial tachycardia were treated successfully with propafenone. "
8.	esmolol (Brevibloc)FDA LinkGeneric 01/01/2013 - "The early effect of esmolol on exercise-induced tachycardia was significantly greater among Arg389 than in Gly389 homozygote healthy individuals (NCT01388036)." 02/01/1994 - "Esmolol, an ultrashort-acting beta-adrenergic blocking agent, has been reported in western published reports to have good results and few side effects in the treatment of supraventricular tachyarrhythmia. " 03/01/1991 - "A double-blind, randomised study was conducted to examine the efficacy of a single bolus dose of esmolol in treating surgically-induced tachycardia. " 07/01/1990 - "A randomized, double-blind, parallel, placebo-controlled study was conducted to determine the safety and efficacy of intravenous (IV) bolus administration of esmolol in treating intraoperative tachycardia in patients undergoing noncardiac general surgery. " 08/01/1988 - "This study supports previous observations concerning the safety and efficacy of esmolol in the treatment of supraventricular tachyarrhythmias. "
9.	Propranolol (Inderal)FDA LinkGeneric 06/01/1981 - "In conclusion, low-dose propranolol is very effective in preventing supraventricular tachyarrhythmia following aorta-coronary bypass in patients receiving beta blockers preoperatively. " 01/01/2012 - "The tachycardia was treated successfully with propranolol for several weeks. " 09/01/2009 - "Low-dose oral propranolol significantly attenuated tachycardia and improved symptoms in POTS. " 09/01/2009 - "Although the high dose elicited a greater decrease than the low dose in standing heart rate (P<0.001) and orthostatic tachycardia (P<0.001), the improvement in symptoms at 2 hours was greater with low-dose propranolol (-6 versus -2 arbitrary units; P=0.041). " 12/01/1989 - "The efficacy of intravenous propranolol for suppression of inducibility of sustained ventricular tachyarrhythmias (VT) was studied in 24 patients who had failed greater than or equal to 1 membrane-active antiarrhythmic drug (mean 2.2 +/- 1.2 drugs/patient). "
10.	Adenosine Triphosphate (ATP)IBA 12/07/2015 - "In the catheter ablation for AF, we found no significant reduction in the 1-year incidence of recurrent atrial tachyarrhythmias by ATP-guided PVI compared with conventional PVI." 04/01/2007 - "ATP has had less efficacy for faster VTs (41-79%) and have higher probability of accelerating tachycardia (5-55%). " 04/01/1990 - "Intravenous adenosine triphosphate during wide QRS complex tachycardia: safety, therapeutic efficacy, and diagnostic utility." 11/01/1989 - "We conclude that adenosine triphosphate is a useful, safe and effective drug at low dose in correctly diagnosed reentrant tachycardias involving the atrioventricular node. " 11/01/1989 - "Intravenous adenosine triphosphate has been proved to be useful for the treatment of supraventricular tachyarrhythmias. "

Therapies and Procedures

1.	Implantable Defibrillators (Implantable Cardioverter-Defibrillator) 02/01/2014 - "The implantable cardioverter/defibrillator (ICD) is the most effective treatment for malignant ventricular tachyarrhythmias. " 03/01/2012 - "Implantable cardioverter defibrillators (ICDs) have been demonstrated to be highly effective for the prevention of sudden arrhythmic death in IVNC and should be considered in patients who are clinically judged to be at high risk for ventricular tachyarrhythmias. " 01/01/2006 - "A number of important randomized clinical trials on the efficacy of prophylactic implantable cardioverter defibrillator therapy in patients deemed to be at high risk for ventricular tachyarrhythmias have recently reported their results. " 10/01/1997 - "The implantable cardioverter-defibrillator (ICD) is an implantable electronic device that has been proven to be safe and effective in treating various malignant tachyarrhythmias in susceptible individuals. " 04/07/2001 - "Implantable cardioverter defibrillators (ICDs) have evolved from the treatment of last resort to the gold standard therapy for patients at high risk for ventricular tachyarrhythmias. "
2.	Catheters 08/01/1986 - "In addition, preliminary experience suggests that the catheter technique may be highly effective for patients with tachycardia incorporating a posteroseptal accessory pathway. " 03/01/2003 - "The use of three dimensional electroanatomical mapping(CARTO system) to evaluate the reentry circuit after the detection of abnormal potentials by using multipolar catheter in advance is a very useful method to determine optimal target site of ablation for a patient with incisional reentrant atrial tachycardia." 02/15/1995 - "Termination of tachycardia in the anterograde direction at the longest atrial coupling interval by extrastimuli delivered from the ablating catheter can be helpful for identification of an optimal site for slow-pathway ablation in patients with the common variety of AVNRT." 04/01/2006 - "However, persistent tachyarrhythmias can often be treated successfully with catheter mapping and ablation." 02/01/2005 - "Because mapping of the right ventricular outflow tract was not successful, the catheter was placed inside the pulmonary artery with satisfactory mapping of the arrhythmogenic focus, and tachycardia was eliminated as soon as radiofrequency was initiated. "
3.	Defibrillators (Defibrillator) 09/01/2002 - "Atrial antitachy pacing and shock therapies demonstrated very high efficacy in treating atrial tachyarrhythmias in defibrillator patients." 05/01/2006 - "Ventricular tachyarrhythmia induction by strong cardiac shocks: can understanding underlying mechanisms lead to improved prevention of defibrillator failure?" 08/01/1985 - "The available data indicate that the automatic cardioverter-defibrillator can reliably identify and correct potentially lethal ventricular tachyarrhythmias, leading to a substantial improvement in survival in properly selected high risk patients." 07/01/2007 - "The Multicenter UnSustained Tachycardia Trial (MUSTT) investigated whether electrophysiologic study (EPS) was helpful in choosing drug or defibrillator therapy in patients induced into sustained VT. " 01/01/1993 - "Our experience shows that the transvenous Medtronic Pacer Cardioverter Defibrillator System provides safe, effective treatment of ventricular tachyarrhythmias. "
4.	Electric Countershock (Cardioversion) 01/20/1993 - "11 out of 17 patients (65%) experienced one or more episodes of tachyarrhythmias which was treated successfully with overdrive pacing (ramp or burst), cardioversion or defibrillation. " 02/01/1978 - "In a large number of cases, electrotherapeutical approaches such as DC-cardioversion and cardiac pacing are effective in controlling ectopic tachycardias. " 01/01/2011 - "Efficacy of low energy rectilinear biphasic cardioversion for regular atrial tachyarrhythmias." 11/01/1993 - "A tachycardia-related efficacy of 69% and patient-related efficacy of 46% of the low-energy cardioversion < or = 4 joules was observed. " 11/01/2014 - "From 1998 to 2012, patients admitted to the emergency department for persistent, non-self-terminating atrial tachyarrhythmia lasting >2 days who gave informed consent for TEE-guided cardioversion were prospectively enrolled in the study. "
5.	Cryosurgery 05/01/2009 - "The purpose of this study was to evaluate the safety and efficacy of cryoablation as an alternative to radio frequency (RF) ablation in high-risk-located atrial tachycardia (AT). " 11/01/2005 - "Cryoablation at a mid-septal location under three-dimensional guidance successfully eliminated both tachycardias without detrimental effects to the AV node." 06/01/2012 - "Transcatheter cryoablation for atrioventricular junctional re-entrant tachycardia in children and adolescents is as effective as radiofrequency ablation over the medium term. " 10/01/2010 - "Current experiences indicate that cryoablation for AV-nodal reentry tachycardia is effective and safe. " 03/01/1985 - "The single exception at the present time is surgery for AV node reentry tachycardia, which appears to be easily cured by the new technique of discrete cryosurgery of the peri-AV nodal region of the lower right atrial septum. "