Abstract |
The objective of the present research was to evaluate dietary supplementation of essential oils from Lippia origanoides (LEO) on necrotic enteritis (NE). Chickens were randomly assigned to three groups. Group 1: negative control; Group 2: positive control challenged with Salmonella typhimurium (day 1), Eimeria maxima (day 18), and C. perfringens (CP, days 22-23); Group 3: dietary supplementation LEO and challenged. On d 25 of age, serum samples were collected to evaluate fluorescein isothiocyanate-dextran ( FITC-d), superoxide dismutase (SOD), gamma interferon (IFN-γ), Immunoglobulin A ( IgA). Group 3 showed a significant reduction of the harmful effects of induced infection/ dysbiosis and a significant reduction in NE lesion scores, morbidity and mortality compared with the positive challenge control group (p < 0.05) compared with Group 2. Digested feed supernatant, supplemented with LEO and inoculated with CP, reduced CP burden (p < 0.05). Group 3 also exhibited a significant reduction in FITC-d, IFN-γ and IgA compared with Group 2. However, a significant increase SOD was observed in Group 3 compared with both control groups. Further investigation to compare the effect of LEO and the standard treatment of clostridial NE is required.
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Authors | Makenly E Coles, Aaron J Forga, Roberto Señas-Cuesta, Brittany D Graham, Callie M Selby, Álvaro J Uribe, Blanca C Martínez, Jaime A Angel-Isaza, Christine N Vuong, Xochitl Hernandez-Velasco, Billy M Hargis, Guillermo Tellez-Isaias |
Journal | Animals : an open access journal from MDPI
(Animals (Basel))
Vol. 11
Issue 4
(Apr 13 2021)
ISSN: 2076-2615 [Print] Switzerland |
PMID | 33924404
(Publication Type: Journal Article)
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